… mortality and morbidity through its effects on target organs like the brain, heart, … target organ
damage. In this review, we describe damages related to hypertension in these target organs …

… 2 novel transgenic mouse models containing the human renin (hREN) gene encoded on P1
… form of active renin. Double transgenic mice containing a PAC transgene and the human …

… Human renin and human angiotensinogen transgenic mice were generated at the … both
human renin and AGT transgenes were generated by breeding human renin mice with human …

… Inhibitors of the system—ie, angiotensin converting enzyme inhibitors and angiotensin
receptor blockers, are now first-line treatments for hypertensive target organ damage and …

… binding of renin to the receptor can have profibrotic effects that are independent of Ang II,
suggesting direct actions of renin and prorenin on organ pathophysiology22). Renin itself or …

… crine or paracrine influences on target organ function [6—10]. … renin in key target organs.
Immunohistochemistry has been used to demonstrate renin immunoreactivity in several organs […

… renin-angiotensin-aldosterone system (RAAS) is a well known regulator of blood pressure
(BP) and determinant of target-organ … RAAS, such as the renin inhibitors or the vasopeptidase …

… However, chronic unrelenting stimulation of renin cells leads to severe kidney … of renin
cells within the kidney and immune compartments and the consequences of distorting the renin …

… renin, as renin was not expressed in Xenopus embryos at the early phase of development
when the studies were performed, and Drosophila and Hydra have no renin… human (pro)renin …

… Steps “b”, “c”, and “d” are known to be enzymatically mediated, while “a” and “e” involve
interactions at the receptor level in different tissues or target organs. The reason for making this …