… human renin inhibitor aliskiren to test the efficacy of the compound in preventing progression
of pre-existing albuminuria and target organ … possibility of ameliorating target organ injury, a …

… Renin is the rate-limiting enzyme of the renin-angiotensin system … properties make renin a
potentially attractive target to inhibit the renin-… Inhibition of renin reduces blood pressure and …

… The ultimate goal of treating hypertension is reduction of morbidity, mortality and target
organ damage, so that analysis restricted to blood pressure measurement clearly is simplistic. …

… Even though this woman does not have severe hypertension, even moderately elevated
arterial pressure in patients with diabetes can pose serious long-term risks for target organ …

… Subfornical organ-selective deletion of the PRR by intracerebroventricular adeno-associated
virus-PRR-short-hairpin RNA delivery in double-transgenic mice expressing human renin …

… Evidence for the potential role of organ specific cardiovascular renin–angiotensin systems (…
; structural and functional changes of the target organs associated with prolonged dietary salt …

… for renin and its precursor, prorenin, named the (pro)renin receptor [(P)RR], has modified our
conception of renin as … Renin and prorenin binding to the receptor allows these enzymes to …

… However, for study of the human renin-angiotensin system in the rat for … human renin-angiotensin
system for generation of Ang II. We measured components of the rat and human renin-…

… for hypertension, especially in patients with hypertensive target organ damage [11]. Regarding
the … Recently the development of an oral active renin inhibitor has provided an alternative …

… of the renin-angiotensin system (RAS) in the pathophysiology of hypertension and organ injury
… Proximal tubular angiotensinogen, collecting duct renin, and tubular angiotensin II type 1 (…