Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome

Y Le Tulzo, C Pangault, A Gacouin, V Guilloux, O Tribut… - Shock, 2002 - journals.lww.com
… , we evaluated circulating lymphocyte apoptosis in 23 septic shock, 25 sepsis without shock,
7 … In patients with sepsis, we compared day 1 lymphocyte apoptosis (ie, within 3 days of the …

Leukocyte apoptosis and its significance in sepsis and shock

DE Wesche, JL Lomas-Neira, M Perl… - Journal of leukocyte …, 2005 - academic.oup.com
… Hotchkiss and co-workers [44, 45] have shown an increase in splenic lymphocyte apoptosis
in septic mice, which is associated with an increase in mortality. Lymphocyte apoptosis may …

Enhanced T-cell apoptosis in human septic shock is associated with alteration of the costimulatory pathway

PM Roger, H Hyvernat, JP Breittmayer… - European journal of …, 2009 - Springer
… We, therefore, studied lymphocyte’s cytokine secretion upon stimulation through CD3-CD28.
As shown in Fig. 3a, among interferon-γ, IL-2 and TNF-α, only IL-2 kinetics were clearly …

Lymphocyte apoptosis, caspase activation and inflammatory response in septic shock

G Delogu, G Famularo, G Tellan, M Marandola… - Infection, 2008 - Springer
… during sepsis [5–9]. In this note we report a study carried out on 16 intensive care patients
who developed septic shock. Within 24 h after the diagnosis we explored lymphocytes

Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans

RS Hotchkiss, KW Tinsley, PE Swanson… - The Journal of …, 2001 - journals.aai.org
… Finally, we examined the role of active caspase-9 in lymphocyte apoptosis in sepsis. Apoptosis
… Knowledge of the precise pathway of apoptosis will help identify stimuli that trigger cell …

Sepsis-induced human lymphocyte apoptosis and cytokine production in “humanized” mice

J Unsinger, JS McDonough, LD Shultz… - Journal of leukocyte …, 2009 - academic.oup.com
… of sepsis. In particular, the effect of sepsis on human lymphocyte apoptosis and human pro-
… in a clinically relevant mouse peritonitis model of sepsis. The development of this model will …

Upregulation of reactive oxygen species generation and phagocytosis, and increased apoptosis in human neutrophils during severe sepsis and septic shock

PS Martins, EG Kallas, MC Neto, MA Dalboni… - Shock, 2003 - journals.lww.com
… In this study, we evaluated neutrophil activation in severe sepsis and septic shock by … )
demonstrated that lymphocyte apoptosis is increased in blood of patients in septic shock. …

Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways

RS Hotchkiss, SB Osmon, KC Chang… - The Journal of …, 2005 - journals.aai.org
lymphocyte apoptosis in human sepsis with the annexin V method used in the present
study. They reported that patients with septic shock had an increase in lymphocyte apoptosis to …

[HTML][HTML] Apoptosis-induced lymphopenia in sepsis and other severe injuries

T Girardot, T Rimmelé, F Venet, G Monneret - Apoptosis, 2017 - Springer
… for lymphocyte death in sepsis and other injuries [13–15]. This review focuses on the
consequences of lymphocyte apoptosis in … of lymphocytes purified from septic shock patients’ …

Increased DNA damage and increased apoptosis and necrosis in patients with severe sepsis and septic shock

I Bahar, G Elay, G Başkol, M Sungur… - Journal of critical …, 2018 - Elsevier
Apoptosis of lymphocytes can be an adaptive response, which may activate counter-…
apoptotic and necrotic cell death of lymphocytes in patients with severe sepsis and septic shock, …