… between human serum albumin (HSA) and four approved epidermal growth factor receptor
(EGFR) inhibitors gefitinib (… The EGFR inhibitors were predominantly presented in their single …

… Gefitinib, a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, has
… non-small cell lung cancer patients with tumors carrying sensitive EGFR mutation. However, …

… Thus, in this study, the interaction between EGFR inhibitor (small molecule TKIs such as
GEF) and multikinase inhibitor (REG) was suggested to represent a promising combination for …

… kinase inhibitors (TKIs), such as gefitinib, lapatinib and sunitinib, with bovine serum albumin
(BSA) … and configuration with human serum albumin (HSA), clear structure and low cost [8]. …

… Among the wide variety of anticancer drugs used in clinical routine, gefitinib (GEF) is one
of … 1) competes with ATP for the ATP-binding site of the epidermal growth factor receptor (EGFR…

… Gefitinib (Iressa®) is a selective inhibitor of epidermal growth … as gefitinib (Iressa®), that
inhibit the kinase activity of EGFR … Gefitinib is highly bound to human plasma albumin and α1-…

… and 78% of gefitinib was bound to human serum albumin (HSA) … gefitinib is highly protein
bound (∼ 97%) in human plasma. … Gefitinib targets the ATP cleft within the EGFR-TK to prevent …

… evaluate the binding interaction of gefitinib (GEF) with human serum albumin (HSA) and calf
… binding between anticancer drug gefitinib as a tyrosine kinase inhibitor with HSA and DNA …

… effects of gefitinib on cell cycle were determined by flow cytometry and the molecular effects
of gefitinib EGFR inhibition on downstream signal proteins by Western blotting. Gefitinib in …

… Although the EGFR inhibitors are orally active and have … the efficacy of combination therapies
with EGFR inhibitors. … saline containing 450 nM bovine serum albumin (BSA). Excitation …