Annotation of the human serum metabolome by coupling three liquid chromatography methods to high-resolution mass spectrometry

S Boudah, MF Olivier, S Aros-Calt, L Oliveira… - … of Chromatography B, 2014 - Elsevier
methods for their coverage of human serum metabolome. … and versatility of liquid
chromatography coupled to high … of the human serum metabolome. To this end, three different …

[HTML][HTML] The human serum metabolome

N Psychogios, DD Hau, J Peng, AC Guo, R Mandal… - PloS one, 2011 - journals.plos.org
… Overall, it appears that LC-MS or DI-MS methods may be the best choice for serum
metabolomic studies, despite their bias against hydrophilic metabolites. Interestingly, the use of …

[HTML][HTML] Defining blood plasma and serum metabolome by GC-MS

O Kiseleva, I Kurbatov, E Ilgisonis, E Poverennaya - Metabolites, 2021 - mdpi.com
Metabolomics uses advanced analytical chemistry methods to analyze metabolites in …
of human plasma and serum using mass spectrometry combined with gas chromatography. …

[HTML][HTML] Targeted metabolomics identifies reliable and stable metabolites in human serum and plasma samples

M Breier, S Wahl, C Prehn, M Fugmann, U Ferrari… - PloS one, 2014 - journals.plos.org
… targeted metabolomics approach was based on electrospray ionization liquid chromatography
Based on our data, the optimal method of sample shipment in multicenter trials is to collect …

Analysis of the adult human plasma metabolome

KA Lawton, A Berger, M Mitchell, KE Milgram… - …, 2008 - Taylor & Francis
Methods: Using gas- and liquid-chromatographymetabolomic results, it is important to
determine the effects of age, sex and race on human plasma metabolites (ie, plasma metabolome

Development and performance of a gas chromatography− time-of-flight mass spectrometry analysis for large-scale nontargeted metabolomic studies of human serum

P Begley, S Francis-McIntyre, WB Dunn… - Analytical …, 2009 - ACS Publications
… A method for the preparation and GC−TOF-MS analysis of human serum samples has
been developed and evaluated for application in long-term metabolomic studies. …

Development of a robust and repeatable UPLC− MS method for the long-term metabolomic study of human serum

E Zelena, WB Dunn, D Broadhurst… - Analytical …, 2009 - ACS Publications
… was specifically designed to fulfill the requirements of a long-term metabolomic … of serum
samples from 30 healthy individuals. We also assessed the reproducibility of chromatographic

[HTML][HTML] Molecular phenotyping of a UK population: defining the human serum metabolome

WB Dunn, W Lin, D Broadhurst, P Begley, M Brown… - Metabolomics, 2015 - Springer
chromatographic MS-based metabolomics study, using samples from over 1,000 individuals,
to provide a comprehensive measurement of their serum metabolomes. … methods able to …

… profiling of human serum in lung cancer patients using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry and gas chromatography/mass …

Y Chen, Z Ma, A Li, H Li, B Wang, J Zhong… - Journal of cancer …, 2015 - Springer
Metabolomic methods have developed rapidly and have become effective tools for disease
Metabolomic studies in lung cancer patient samples have generally employed techniques

[HTML][HTML] Impact of prolonged blood incubation and extended serum storage at room temperature on the human serum metabolome

B Kamlage, S Neuber, B Bethan… - Metabolites, 2018 - mdpi.com
blood incubation and extended serum storage at RT on the human serum metabolome using
gas chromatography-… The high sensitivity of modern analytical techniques coupled with the …