… and trigger a pro-inflammatory response. This article will highlight what is known about the
biology of the CD40-CD40L axis in humans and describe the potential contribution of CD40 …

… role of CD40/CD40L in the regulation of humoral immunity. … CD40/CD40L interacts are in
generating humoral immunity is … in the CD40L gene which generate non-functional CD40L. …

… hyper-IgM syndrome fail to express functional CD40 ligand (CD40L) and, as a … of CD40L
in humoral immunity, we created, through homologous recombination, mice deficient in CD40L …

… Finally, there are a number of additional aspects of humoral immunity whose dependence
on CD40L has yet to be ascertained. Several studies have documented a role for CD40 in the …

… Although initially thought of as a B cell deficiency, activated T cells from HIM patients
surprisingly displayed no binding with CD40-Ig fusion proteins or Abs against CD40L, even though …

… that CD40 and CD40L are important regulators of a variety of humoral and cellular immune
… memory are all defective in the absence of the CD40L-CD40 interaction [53]. However, these …

… dependent on signals provided through the CD40-CD40L interaction. However, novel …
CD40L and CD40 molecules may extend well beyond their role in the humoral immune response…

… studies clearly establish a role for CD40L in the activation and … effects of CD40L on other cell
types expressing CD40. Consequently… compromised humoral immune responses in CD40L-…

… ligand for CD40 (gp39; CD40L) as the cardinal element in the initiation of humoral immune
… unlike the essential function of CD40L in TD humoral immunity, the capacity of CD40L in the …

… to be involved only in regulating humoral immunity, 3) with the … of CD40L/CD40 in the
development of TD humoral immunity, evidence began to accumulate indicating that CD40L/CD40 …