Improved oral delivery of tilianin through lipid–polymer hybrid nanoparticles to enhance bioavailability

C Zeng, R Zheng, X Yang, Y Du, J Xing… - … and Biophysical Research …, 2019 - Elsevier
… low bioavailability. The present study aimed to formulate lipid–polymer hybrid nanoparticles
(LPHNs) as carriers for the sustained release and oral bioavailability enhancement of TIL in …

Development of novel self-assembled DS-PLGA hybrid nanoparticles for improving oral bioavailability of vincristine sulfate by P-gp inhibition

G Ling, P Zhang, W Zhang, J Sun, X Meng, Y Qin… - Journal of controlled …, 2010 - Elsevier
Enhancement of bioavailability of cytotoxic agents is a pre-requisite for successful …
bioavailability of VCR, we attempted to develop novel dextran sulphate-PLGA hybrid nanoparticles (…

Harnessing lipid polymer hybrid nanoparticles for enhanced oral bioavailability of thymoquinone: in vitro and in vivo assessments

SS Imam, SJ Gilani, MN Bin Jumah, M Rizwanullah… - Polymers, 2022 - mdpi.com
bioavailability. Herein, this investigation aimed to develop THQ-loaded lipid-polymer hybrid
nanoparticles (… Furthermore, the THQ-LPHNPs showed 4.74-fold enhanced bioavailability

Development of sustained release baricitinib loaded lipid-polymer hybrid nanoparticles with improved oral bioavailability

MK Anwer, EA Ali, M Iqbal, MM Ahmed, MF Aldawsari… - Molecules, 2021 - mdpi.com
… data showed an enhancement (2.92 times more) in bioavailability in comparison to the …
hybrid nanoparticles could be a promising drug delivery option to enhance the bioavailability of …

Carbon dioxide-mediated generation of hybrid nanoparticles for improved bioavailability of protein kinase inhibitors

G Jesson, M Brisander, P Andersson… - Pharmaceutical …, 2014 - Springer
hybrid nanoparticles are efficient in enhancing dissolution rate and improving oral bioavailability
… presence of surfactant is critical for maximally enhanced in vitro dissolution rates and GI …

Bioadhesive polymer/lipid hybrid nanoparticles as oral delivery system of raloxifene with enhancive intestinal retention and bioavailability

X Du, N Gao, X Song - Drug delivery, 2021 - Taylor & Francis
… After oral administration, RLX-bNPs resulted in significant enhancement in the bioavailability
of RLX, up to 556.9% relative to RLX suspensions, while it was merely 244.7% for RLX-…

Core shell lipid-polymer hybrid nanoparticles for oral bioavailability enhancement of ibrutinib via lymphatic uptake

M Patel, A Desai, V Kansara, B Vyas - AAPS PharmSciTech, 2023 - Springer
… IBR)-loaded lipid-polymer hybrid nanoparticles (IBR-LPHNPs) to … The oral bioavailability of
IBR was improved 22.52-fold with … a promising approach to improve oral bioavailability of IBR. …

Polymer-lipid hybrid nanoparticles of exemestane for improved oral bioavailability and anti-tumor efficacy: An extensive preclinical investigation

M Rizwanullah, A Perwez, M Alam, S Ahmad… - International Journal of …, 2023 - Elsevier
bioavailability and anti-breast cancer efficacy of EXE. In this perspective, EXE-loaded
TPGS-based polymer lipid hybrid nanoparticles (… potential in improving oral bioavailability, safety, …

Cholate-modified polymer-lipid hybrid nanoparticles for oral delivery of quercetin to potentiate the antileukemic effect

J Yin, Y Hou, X Song, P Wang, Y Li - International journal of …, 2019 - Taylor & Francis
… QUE-cPLNs resulted in significantly enhanced bioavailability of QUE, up to 375.12%
relative to the formulation of suspensions. In addition, QUE-cPLNs exhibited excellent cellular …

Development of lipid–polymer hybrid nanoparticles for improving oral absorption of enoxaparin

B Tang, Y Qian, G Fang - Pharmaceutics, 2020 - mdpi.com
… oral bioavailability of enoxaparin could be improved by lipid–polymer hybrid nanoparticles.
… is the precondition of oral absorption enhancement by nanoparticles. There are several …