… and safety of hypoxia-inducible factor prolyl hydroxylase inhibitors in patients with chronic kidney disease: meta-analysis of phase 3 randomized controlled trials

R Minutolo, ME Liberti, V Simeon… - Clinical Kidney …, 2024 - academic.oup.com
… Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are new therapeutic
agents for … We selected phase 3 randomized clinical trials (RCTs) comparing HIF-PHIs and …

Effect of hypoxia-inducible factor-prolyl hydroxylase inhibitors on anemia in patients with CKD: a meta-analysis of randomized controlled trials including 2804 patients

B Wang, Q Yin, YC Han, M Wu, ZL Li, Y Tu, L Zhou… - Renal failure, 2020 - Taylor & Francis
… all clinical trials (confined to phase II or III) about HIF-PHIs on anemia treatment. Hence, we
first conducted a meta-analysis of randomized controlled trials (… randomized controlled trials

[HTML][HTML] Hypoxia-inducible factor prolyl hydroxylase inhibitors: a potential new treatment for anemia in patients with CKD

N Gupta, JB Wish - American Journal of Kidney Diseases, 2017 - Elsevier
… yet to be proved in long-term clinical trials. One significant concern … clinical trials in the
United States; this report provides a focused review of HIF-PH inhibitors and their potential clinical

[HTML][HTML] Prolyl hydroxylase domain inhibitors as a novel therapeutic approach against anemia in chronic kidney disease

M Sugahara, T Tanaka, M Nangaku - Kidney international, 2017 - Elsevier
randomized controlled studies have demonstrated that the use of ESAs with a target
hemoglobin level of >13 g/dl has been associated with an increased rate of cardiovascular events …

… inducible factor-prolyl hydroxylase inhibitors in anemic patients with non-dialysis dependent chronic kidney disease: a meta-analysis of randomized clinical trials

MMG Mohamed, M Oyenuga, S Shaikh… - … Urology and Nephrology, 2023 - Springer
… We conducted a meta-analysis of randomized clinical trials to assess the efficacy and safety
of HIF-PHI in non-dialysis-dependent CKD patients. Primary outcome was hemoglobin (Hb) …

Effects of hypoxia-inducible factor prolyl hydroxylase inhibitors on iron regulation in non-dialysis-dependent chronic kidney disease patients with anemia: a systematic …

J Li, QH Xie, L You, NX Xu, CM Hao - Pharmacological Research, 2021 - Elsevier
… showed that hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) … among clinical
trials. We performed a systematic review and meta-analysis of randomized controlled trials

Long‐term efficacy and safety of hypoxia‐inducible factor prolyl hydroxylase inhibitors in anaemia of chronic kidney disease: A meta‐analysis including 13,146 …

H Chen, Q Cheng, J Wang, X Zhao… - Journal of clinical …, 2021 - Wiley Online Library
Randomized controlled trials comparing treatment with HIF-PHD inhibitors versus placebo …
and international clinical trial registries. Meta-analysis was performed on main outcomes with …

Four-week studies of oral hypoxia-inducible factor–prolyl hydroxylase inhibitor GSK1278863 for treatment of anemia

L Holdstock, AM Meadowcroft, R Maier… - Journal of the …, 2016 - journals.lww.com
… For the final data set and for all analyses (including hemoglobin), blood was sent to Quest
Diagnostic Clinical Trials for analysis. Other laboratory tests were also analyzed centrally by …

A Prospective Randomized Controlled Clinical Study to Investigate the Efficacy and Safety of Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitors in Non-Dialysis …

A Sezai, M Abe, T Maruyama, M Taoka… - Journal of Clinical …, 2024 - mdpi.com
… We performed a prospective, randomized, controlled study to … types of HIF-PH inhibitors.
The primary endpoint was a … the first head-to-head comparative study of HIF-PH inhibitors. …

Hypoxia-inducible factor prolyl hydroxylase inhibitors in patients with renal anemia: a meta-analysis of randomized trials

T Wen, X Zhang, Z Wang, R Zhou - Nephron, 2020 - karger.com
… Background: Hypoxia-inducible factor prolyl hydroxylase inhibitors (… randomized controlled
trials (RCTs). Information about efficacy and safety was extracted and combined using random