Hypermethylation of the hMLH1 Gene Promoter in Human Gastric Cancers with Microsatellite Instability

AS Fleisher, M Esteller, S Wang, G Tamura, H Suzuki… - Cancer research, 1999 - AACR
… This hypermethylation has been associated with hMLH1hMLH1 gene inactivation and
MMR deficiency. Therefore, we studied the prevalence of hMLH1 promoter hypermethylation in a …

Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia

AS Fleisher, M Esteller, G Tamura, A Rashid, OC Stine… - Oncogene, 2001 - nature.com
… repair gene promoter and diminished hMLH1hMLH1 hypermethylation has not been
studied in early gastric neoplasms. We therefore investigated hMLH1 hypermethylation, hMLH1

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

JG Herman, A Umar, K Polyak… - Proceedings of the …, 1998 - National Acad Sciences
methylation. To address these questions, we have analyzed hMLH1 promoter methylation
in several subtypes of CRC, including those with known mutations of MMR genes. We have …

Hypermethylation of the hMLH1 Promoter in Colon Cancer with Microsatellite Instability

JM Cunningham, ER Christensen, DJ Tester, CY Kim… - Cancer research, 1998 - AACR
… , we have examined the methylation status of the pre sumptive hMLHl promoter region in 31
… hMLHl protein expression (MLH- or MLH+), and their gene mutation (Mut+ or Mut-) status. …

[HTML][HTML] hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis

M Esteller, L Catasus, X Matias-Guiu, GL Mutter… - The American journal of …, 1999 - Elsevier
… between hMLH1 promoter hypermethylation, loss of hMLH1 … involvement of aberrant
methylation of hMLH1 in UEC with … genes, and we show that hMLH1 promoter hypermethylation

Promoter hypermethylation: an important epigenetic mechanism for hMLH1 gene inactivation in head and neck squamous cell carcinoma

K Liu, H Huang, P Mukunyadzi, JY Suen… - … -Head and Neck Surgery, 2002 - Elsevier
… mutations in hMLH1 in sporadic … hMLH1 gene in association with promoter hypermethylation.
It has been documented that hypermethylation of the hMLH1 gene promoter causes gene

[HTML][HTML] Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer

HM Nan, YJ Song, HY Yun, JS Park… - World journal of …, 2005 - ncbi.nlm.nih.gov
hypermethylation of the hMLH1 gene promoterhypermethylation of the hMLH1 gene
promoter and environmental factors, genetic polymorphisms of major metabolic enzymes, genetic

[HTML][HTML] Hypermethylation of the hMLH1 gene promoter in solitary and multiple gastric cancers with microsatellite instability

K Sakata, G Tamura, Y Endoh, K Ohmura… - British journal of …, 2002 - nature.com
… frequent hypermethylation of the hMLH1 gene promoter in … cancers with MSI-H, methylated
alleles were rarely detected in … that hypermethylation of the hMLH1 gene promoter occurs in …

Methylation in hMLH1 promoter interferes with its binding to transcription factor CBF and inhibits gene expression

G Deng, A Chen, E Pong, YS Kim - Oncogene, 2001 - nature.com
… luciferase gene in the plasmids can also be methylated by … methylation of hMLH1 promoter
from that by the methylation of … carries a short proximal promoter sequence without HhaI or …

Promoter hypermethylation and inactivation of hMLH1, a DNA mismatch repair gene, in head and neck squamous cell carcinoma

K Liu, C Zuo, QK Luo, JY Suen, E Hanna… - Diagnostic Molecular …, 2003 - journals.lww.com
… appears to be primarily involved in the inactivation of the hMLH1 gene in sporadic form of …
HNSCC for hMLH1 protein expression and promoter hypermethylation by IHC and methylation-…