… To our knowledge, hyperpolarized gas MR lung imaging has not been previously evaluated
… whether hyperpolarized 3 He lung ventilation imaging can detect the reversible ventilation …

… with hyperpolarized 3He to explore lung ventilation with high temporal and spatial resolution
in small animal models. Ventilation … resolution of F100 m using hyperpolarized 3He. The RA-…

… hyperpolarized 3 He three-dimensional lung … ventilation defects per image (VDI) and the
ventilated lung fraction (VF), defined as the ratio of ventilated lung volume divided by total lung …

… controlled, small-animal ventilator that delivers small volumes of hyperpolarized 3 He mixed
with oxygen to the mouse with low dead volume. The ventilator design is compatible with …

… human lungs with hyperpolarized 3He, both in healthy volunteers and in patients with lung
disor… The pigs we have imaged have been deeply anesthetized, requiring external ventilation …

… Regions of diminished ventilation are often evident during functional pulmonary imaging
studies, including hyperpolarized gas magnetic resonance imaging (MRI), positron emission …

… Hyperpolarized 3 He MRI provides an opportunity to visualize those areas of the lung
that participate in ventilation and those that do not. This is particularly true for the terminal …

… Therefore, our objective here was to evaluate hyperpolarized 3 He MRI ventilation
abnormalities, pulmonary function test measurements, and the frequency of exacerbations for five …

… This study demonstrates that the flow and distribution of hyperpolarized 3He in the lungs …
three, so that ventilation in the upper, mid and lower portions of the lungs could be compared; …

… We modified our existing computer-controlled ventilator by … Ideally, for hyperpolarized (HP)
3He studies of lungs, HP 3He … effect on HP 3He.An additional problem for small animal …