… in SHRs (spontaneously hypertensive rats) of RNAi (RNA interference) targeting ACE (…
, 15–37% of adults have hypertension. The prevalence of hypertension even increases to 50…

… Eligible patients included adults 18 to 65 years of age with treated or untreated hypertension
who … Among the key exclusion criteria were secondary hypertension, postural hypotension, …

… Adults with mild to moderate hypertension, defined as daytime mean ambulatory systolic
BP (SBP) of 135 to 160 mm Hg following antihypertensive washout, were randomized. …

… hypertension- a major risk factor for cardiovascular and kidney disease.(1) The therapeutic
landscape of first-line agents for treatment of hypertension … US adults with hypertension have …

… and plays a key role in hypertension pathogenesis. We evaluated the effect of … RNA
interference (RNAi) therapeutic targeting hepatic AGT synthesis, on blood pressure in hypertensive …

… hypertension and may serve as a screening model for novel anti-hypertensive drugs (21). …
To explore its role in hypertension, RNA interference (RNAi) techniques have often been used …

… half of all patients with hypertension are not controlled to guideline-recommended targets
…but treatment of hypertension remains suboptimal despite availability of effective …

… affecting an estimated 1.3 billion adults (aged 30–79 years) … Also, RNA interference leads
to a slow onset of action (days/… hypertension or as a sole therapy in those with hypertensive …

… role of IL-6 in the development of hypertension using the CIH model. We hypothesized that
in vivo knockdown of IL-6 by RNA interference (RNAi) silencing would decrease inflammatory …

… , have unlocked opportunities and developments in clinical trials for RNA interference (RNAi)
as the next medical therapy. RNAi medicine is currently via the utilization of siRNAs and …