… patients with hypertension who did not have serious coexisting conditions. Among patients
… or twice-yearly administration of zilebesiran as a treatment for patients with hypertension. …

… The purpose of the present study was to investigate the effects on blood pressure and
myocardial hypertrophy in SHRs (spontaneously hypertensive rats) of RNAi (RNA interference) …

… Flow of Participants in the KARDIA-1 Trial of Subcutaneous Zilebesiran for Hypertension a A
patient … set, which included all randomized patients who received any amount of study drug. …

… hypertension and may serve as a screening model for novel anti-hypertensive drugs (21). …
To explore its role in hypertension, RNA interference (RNAi) techniques have often been used …

… half of all patients with hypertension are not controlled to guideline-recommended targets
…but treatment of hypertension remains suboptimal despite availability of effective …

… line agents for treatment of hypertension has been transformed by … half of US adults with
hypertension have mean BP (blood … -resistant hypertension, one-third of patients who underwent …

… been implicated in the pathogenesis of hypoxic pulmonary hypertension (PH). However,
the … of hypoxia-induced HIF-1α expression in pulmonary arteries by RNA interference (RNAi) …

… Conversely, lowering plasma AGT levels via targeting of hepatic Agt expression with small
interfering RNA (siRNA) or antisense oligonucleotides in a rat model of hypertension lowers …

… role of IL-6 in the development of hypertension using the CIH model. We hypothesized that
in vivo knockdown of IL-6 by RNA interference (RNAi) silencing would decrease inflammatory …

… and plays a key role in hypertension pathogenesis. We evaluated the … RNA interference
(RNAi) therapeutic targeting hepatic AGT synthesis, on blood pressure in hypertensive patients…