… Hypertonic saline may also have the net effect of decreasing the influence of glutamate
after brain injury. Increasing extracellular sodium can interrupt the feedback loop by helping to …

… of hypertonic saline solutions and elaborates on their use in patients with acute neurologic
injury. … before the use of hypertonic saline solutions can be accepted for widespread use. …

… and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury
… Comparison of mannitol and hypertonic saline in the treatment of severe brain injuries[24] …

… have demonstrated that hypertonic saline has … brain injury with patient survival as an end
point. In this review, we examined the experimental and clinical knowledge of hypertonic saline …

… hypertonic saline in patients who suffered traumatic hemorrhagic shock or traumatic brain
injury … that most deaths occurred within 24 hours of injury, with hemorrhagic shock or TBI as the …

… brain injuries. However, our subgroup analysis of patients with less severe brain injury (…
in hypotensive patients with trauma with severe brain injury. Allocation was concealed and …

… Mannitol and hypertonic saline (HTS) have been studied extensively as hyperosmolar
agents in TBI, but recent meta-analyses have favored hypertonic saline. These studies have …

… Although mannitol is the mainstay of osmolar therapy, hypertonic saline is being used …
hypertonic saline on cerebral blood flow, ICP, and brain water content (10-13) . Hypertonic saline …

… Conclusions and Relevance Among patients with moderate to severe traumatic brain injury,
treatment with continuous infusion of 20% hypertonic saline compared with standard care …

… Our results show that hypertonic saline and mannitol, when used in the same osmotic
burden, are equivalent in the treatment of intracranial hypertension in severe brain injury. The …