Hypertonic saline therapy in cystic fibrosis: do population shifts caused by the osmotic sensitivity of infecting bacteria explain the effectiveness of this treatment?

HD Williams, V Behrends, JG Bundy, B Ryall… - Frontiers in …, 2010 - frontiersin.org
… effects of HS treatment on CF patients. We argue that prolonged HS treatment will select
against osmotically sensitive mucoid strains and in favor of the greater osmotically resistant non-…

Hypertonic saline: a clinical review

R Tyagi, K Donaldson, CM Loftus, J Jallo - Neurosurgical review, 2007 - Springer
… water into the cell, opening stretch-sensitive channels that allow further release of glutamate
[… HTS therapy is the development of neurologic complications due to osmotic demyelination …

Hypertonic saline versus isotonic saline nasal irrigation: systematic review and meta-analysis

D Kanjanawasee, K Seresirikachorn… - American journal of …, 2018 - journals.sagepub.com
Saline nasal lavage is one of the treatments of sinonasal diseases. Evidence from basic
research favors hypertonic saline (HS) over isotonic saline (IS) for mucociliary clearance, but …

The use of hypertonic saline in the treatment of traumatic brain injury

JA Doyle, DP Davis, DB Hoyt - Journal of Trauma and Acute …, 2001 - journals.lww.com
… as an osmotic agent that extracts water from edematous cerebral tissue. Animal and human
studies suggest that HTS possesses osmotic, … Receptors sensitive to both serum sodium and …

Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta-analysis of randomized clinical trials

H Kamel, BB Navi, K Nakagawa… - Critical care …, 2011 - journals.lww.com
… Therefore, to better understand the relative efficacy of these two forms of osmotic therapy, …
the mean and median, we performed sensitivity analyses by excluding such studies altogether …

Hypertonic saline in people with cystic fibrosis: review of comparative studies and clinical practice

V Terlizzi, E Masi, M Francalanci, G Taccetti… - Italian Journal of …, 2021 - Springer
… mucolytic therapy today is mainly based on inhalation of DNase, hypertonic saline or mannitol,
… This review will summarize the current knowledge on hypertonic saline in the treatment of …

Hypertonic saline in severe traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials

E Berger-Pelleiter, M Émond, F Lauzier… - Canadian Journal of …, 2016 - cambridge.org
… to their volume repletion properties and their osmotic effect… Hypertonic saline solutions are
also considered an alternative in … Sensitivity analysis with studies comparing hypertonic saline

Effect of osmotherapy with mannitol or hypertonic saline on cerebral oxygenation and metabolism in patients with intracranial hypertension after severe brain injury

T Suys, H Quintard, C Patet, M Oddo - Critical Care, 2015 - Springer
… These findings support further investigation to test the value of alternative osmotic agents
(such as hypertonic lactate) that may reduce ICP and at the same time improve cerebral …

Impact of isotonic and hypertonic saline solutions on mucociliary activity in various nasal pathologies: clinical study

A Ural, TK Oktemer, Y Kizil, F Ileri… - The Journal of Laryngology …, 2009 - cambridge.org
… any osmotic … , hypertonic saline was reported to be more irritating to the nasal mucosa. In
our study, we did not encounter intolerance to the saline solutions sufficient to stop treatment; …

Hypertonic saline: first-line therapy for cerebral edema?

WC Ziai, TJK Toung, A Bhardwaj - Journal of the neurological sciences, 2007 - Elsevier
Osmotic solutions can be graded by their tonicity, the “effective osmotic forces exerted by …
Furthermore, studies using ion-sensitive microelectrodes have demonstrated that while …