… We demonstrated that MSC cultured in hypoxia activate the Akt signaling pathway while
maintaining their viability and cell cycle rates. We also showed that MSC cultured in hypoxia …

… hypoxia occurs almost immediately. Experiments on the HeLa S3 cell line have shown that
under hypoxic … , HIF-1α can be detected in the cell nucleus within 2 min after exposure. The …

… creates a hypoxic condition for stromal and stem cells. Low oxygen tension has an effect on
different cells in many tissues. Hypoxia has a strong effect on several aspects of cell biology …

… conditions was associated with the induction of hypoxia-inducing factor-alpha (HIF… hypoxic
MSC cultures suggesting an altered metabolism of these human stem cells within the hypoxic …

… ) conditions (usually 2–9% O 2 concentration) on stem cell biology received very little …
and hypoxic conditions. Finally this paper also highlights how MSCs cultured in vitro in hypoxic …

… 8 while some experiments showed that hypoxia induced differentiation.9, 10 Mesenchymal
stem cells (MSCs) can be isolated from a variety of somatic tissues.11 These cells have self-…

… In this study, we demonstrate that hypoxia augments the therapeutic characteristics of both
porcine and human MSCs. Yet, short-term 2% hypoxia offers the greatest benefit overall, …

… We examined the proliferation rates of human stem cells under 5% hypoxic and 20%
normoxic condition through cell proliferation assay. MSC proliferation was assessed by CCK-8 …

… In this study we have analyzed the in vitro response of cryopreserved mesenchymal stem
cells to hypoxic preconditioning at 0.5% oxygen concentration. The results showed that early …

… Hence, it appears that hypoxia can maintain the stem cell characteristics of hMSCs better
than the normoxic conditions traditionally used for cell expansion. Yet, an unexpected result …