Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells
I Rosová, M Dao, B Capoccia, D Link, JA Nolta - Stem cells, 2008 - academic.oup.com
… We demonstrated that MSC cultured in hypoxia activate the Akt signaling pathway while
maintaining their viability and cell cycle rates. We also showed that MSC cultured in hypoxia …
maintaining their viability and cell cycle rates. We also showed that MSC cultured in hypoxia …
Mesenchymal stem cells and hypoxia: where are we?
LB Buravkova, ER Andreeva, V Gogvadze… - Mitochondrion, 2014 - Elsevier
… hypoxia occurs almost immediately. Experiments on the HeLa S3 cell line have shown that
under hypoxic … , HIF-1α can be detected in the cell nucleus within 2 min after exposure. The …
under hypoxic … , HIF-1α can be detected in the cell nucleus within 2 min after exposure. The …
[HTML][HTML] The effect of hypoxia on mesenchymal stem cell biology
M Ejtehadifar, K Shamsasenjan… - Advanced …, 2015 - ncbi.nlm.nih.gov
… creates a hypoxic condition for stromal and stem cells. Low oxygen tension has an effect on
different cells in many tissues. Hypoxia has a strong effect on several aspects of cell biology …
different cells in many tissues. Hypoxia has a strong effect on several aspects of cell biology …
Effects of hypoxic culture conditions on umbilical cord-derived human mesenchymal stem cells
A Lavrentieva, I Majore, C Kasper, R Hass - Cell communication and …, 2010 - Springer
… conditions was associated with the induction of hypoxia-inducing factor-alpha (HIF… hypoxic
MSC cultures suggesting an altered metabolism of these human stem cells within the hypoxic …
MSC cultures suggesting an altered metabolism of these human stem cells within the hypoxic …
Hypoxic culture conditions as a solution for mesenchymal stem cell based regenerative therapy
… ) conditions (usually 2–9% O 2 concentration) on stem cell biology received very little …
and hypoxic conditions. Finally this paper also highlights how MSCs cultured in vitro in hypoxic …
and hypoxic conditions. Finally this paper also highlights how MSCs cultured in vitro in hypoxic …
Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells
SP Hung, JH Ho, YRV Shih, T Lo… - Journal of Orthopaedic …, 2012 - Wiley Online Library
… 8 while some experiments showed that hypoxia induced differentiation.9, 10 Mesenchymal
stem cells (MSCs) can be isolated from a variety of somatic tissues.11 These cells have self-…
stem cells (MSCs) can be isolated from a variety of somatic tissues.11 These cells have self-…
Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells
B Antebi, LA Rodriguez, KP Walker, AM Asher… - Stem Cell Research & …, 2018 - Springer
… In this study, we demonstrate that hypoxia augments the therapeutic characteristics of both
porcine and human MSCs. Yet, short-term 2% hypoxia offers the greatest benefit overall, …
porcine and human MSCs. Yet, short-term 2% hypoxia offers the greatest benefit overall, …
Hypoxia enhances cell properties of human mesenchymal stem cells
SY Kwon, SY Chun, YS Ha, DH Kim, J Kim… - Tissue Engineering and …, 2017 - Springer
… We examined the proliferation rates of human stem cells under 5% hypoxic and 20%
normoxic condition through cell proliferation assay. MSC proliferation was assessed by CCK-8 …
normoxic condition through cell proliferation assay. MSC proliferation was assessed by CCK-8 …
Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells
SM Chacko, S Ahmed, K Selvendiran… - … of Physiology-Cell …, 2010 - journals.physiology.org
… In this study we have analyzed the in vitro response of cryopreserved mesenchymal stem
cells to hypoxic preconditioning at 0.5% oxygen concentration. The results showed that early …
cells to hypoxic preconditioning at 0.5% oxygen concentration. The results showed that early …
Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells
… Hence, it appears that hypoxia can maintain the stem cell characteristics of hMSCs better
than the normoxic conditions traditionally used for cell expansion. Yet, an unexpected result …
than the normoxic conditions traditionally used for cell expansion. Yet, an unexpected result …
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