… osteogenic differentiation. For the first time, we show that hypoxic preconditioning prior to
osteogenic … tension helps to overcome hypoxia-induced inhibition of osteogenic differentiation. …

… in vitro protocols for osteogenic induction. For example, many groups seek to increase the
therapeutic potential of MSCs by preconditioning them under hypoxic environments prior to in …

… shown to promote osteogenic and angiogenic responses… osteogenic differentiation of stem
cells from donors with osteonecrosis of the femoral head, suggesting hypoxia preconditioning …

… as a result of hypoxic preconditioning (5% … osteogenesis was inhibited by hypoxic
preconditioning [29]. Adipogenic differentiation potential has been shown to be enhanced by hypoxic …

… Col1A1 is an indicator of the efficiency of the final osteogenic potential [79]. Therefore, a
lower expression of COL1A1 would indicate a decreased efficiency in osteogenic potential [32]. …

… Notably, we found that HP enhances the survival rate and osteogenic potentials of hDPSCs
by activating specific signaling factors. Previous studies have demonstrated a protective role …

… of a prolonged hypoxia exposure on the osteogenic potential of ASC … are transplanted in a
hypoxic microenvironment. We … Nevertheless, the preconditioning approach did not take into …

… by preconditioning cells in less severe hypoxic conditions (1%–3… hypoxic preconditioning
prior to transplantation improves the tissue-regenerating ability of MSC. The culture in hypoxic …

… the angiogenesis and osteogenesis potential of BMSCs under 1% O 2 … hypoxia preconditioning
inhibits BMSCs death induced by severe condition. Therefore, hypoxia preconditioning …

… the potentially synergistic role of hypoxic preconditioning and … Hypoxic-preconditioned MSC
spheroids were more resistant … of hypoxic preconditioning duration on osteogenic potential …