… spheroids were preconditioned to survive in hypoxic conditions. The expression levels of
HIF-1α, a hypoxia-… in the HUVEC spheroid culture compared with the HUVEC monolayer …

… It has been reported that hypoxic preconditioning results in … we refer to as a hypoxic ASC
spheroid and stimulate cellular … We emphasize the significance of spheroids culture with LLLI …

… In addition, it has been reported that I/R preconditioning is … After exposure to hypoxia for
2 h, cell cultures were … Exposure of PCAECs spheroids to 2 h of hypoxia followed by 24 h …

… Due to a mild hypoxic environment formed in hADSC spheroid, spheroid culture was effective
to precondition the hADSCs to upregulate hypoxia-inducible factor-1α gene expression …

… Our results show that ASCs within spheroids can be further expanded in monolayer culture
… Therefore, hypoxia preconditioning may be a contributing factor to the therapeutic potential …

… Based on the regenerative potential of HPS, we hypothesize that its supplementation to
chondrocyte culture media can prevent or reverse dedifferentiation while maintaining …

… , it is highly pertinent to understand the impact of therapeutic approaches involving
application of hypoxia mimetic agents and hypoxia pre-conditioning on the WNT inhibitors. …

… after 3D spheroid culture express more levels of hypoxia-inducible … Besides improved
tolerance to hypoxia, significant … Bax, has been shown for spheroid-derived MSCs, confirming the …

… insufficiency can lead to cell death, hypoxia has traditionally been viewed as a negative …
control of culture parameters can be used to regulate hypoxic status, thus driving desired cell …

… Based on our previous results, we further optimized hypoxic preconditioning to … spheroid
culture to mimic IR-induced salivary hypofunction, where IR of acinus-like 3D hPEC spheroids …