Hypoxia-activated adipose mesenchymal stem cells prevents irradiation-induced salivary hypofunction by enhanced paracrine effect through fibroblast growth factor …

HS Shin, S Lee, YM Kim, JY Lim - Stem Cells, 2018 - academic.oup.com
… , we further optimized hypoxic preconditioning to enhance … , and 3D acinus-like spheroids
that formed on GFR-Matrigel were … , we observed that the spheroids cocultured with hAdMSC …

The in vitro preconditioning of myoblasts to enhance subsequent survival in an in vivo tissue engineering chamber model

DJ Tilkorn, EM Davies, E Keramidaris, AM Dingle… - Biomaterials, 2012 - Elsevier
… cell death of implanted cells will hamper successful tissue formation [5]. This study therefore
… In the hypoxia preconditioned group we noted considerable variability in myoblast numbers …

Hypoxia Impedes Vasculogenesis of In Vitro Engineered Bone

D Gawlitta, JO Fledderus, MHP van Rijen… - … engineering Part A, 2012 - liebertpub.com
… , the level of hypoxia introduced here did not allow the formation of a … Endothelial progenitor
cell sprouting in spheroid cultures is … Hypoxic preconditioning advances CXCR4 and CXCR7 …

Preconditioning methods to improve mesenchymal stromal cell-derived extracellular vesicles in bone regeneration—a systematic review

FC Hertel, AS Silva, AP Sabino, FL Valente, ECC Reis - Biology, 2022 - mdpi.com
… method of preconditioning. In this study, a more advanced bone formation was observed …
-treated groups; however, hypoxic exosomes showed a significant difference compared to …

3D Hypoxia Microenvironment Created by a Single Cell Layer-by-Layer Assembly Spheroid Demonstrates the Role of miR-382 and Cell Autophagy in Renal Fibrosis

B Hu, Z Yang, L Yu, W Zhang, X Li… - Journal of …, 2018 - ingentaconnect.com
formed a 3D hypoxia multi-cellular spheroid after being treated with trypsin. Based on the
developed 3D hypoxia … culture systems preconditioned in a hypoxia environment via physical7 …

Enhanced angiogenic potential of adipose-derived stem cell sheets by integration with cell spheroids of the same source

J Yu, YC Hsu, JK Lee, NC Cheng - Stem Cell Research & Therapy, 2022 - Springer
… The stimulating effect of spheroid formation on ASCs toward endothelial … the hypoxic core
of cell spheroids [23]. In addition to the hypoxic milieu, the enhanced function of ASC spheroids

Extracellular vesicles derived from hypoxic colorectal cancer cells confer metastatic phenotype to non-metastatic cancer cells

E Endzeliņš, A Ābols, A Bušs, E Zandberga… - Anticancer …, 2018 - ar.iiarjournals.org
… In contrast, hypoxic SW480-derived EVs only marginally increased the spheroid forming
EVs did not have an impact on the spheroid forming ability of SW620 cells (Figure 3B lower …

Intermittent hypoxia enhances the expression of hypoxia inducible factor HIF1A through histone demethylation

CA Martinez, Y Jiramongkol, N Bal, I Alwis… - Journal of Biological …, 2022 - ASBMB
… severe hypoxic event following intermittent hypoxiahypoxia, or intermittent hypoxia that was
immediately followed by an additional acute period of chronic hypoxia (4 h of chronic hypoxia

Hypoxia-induced metastasis: the role of the unfolded protein response

H Mujcic - 2013 - cris.maastrichtuniversity.nl
… model of tumor hypoxia we used spheroid cultures, which … a hypoxic environment allowing
HIFα-HIFβ complex formation … Establishment of such a niche involves preconditioning of the …

Hypoxia-based strategies for angiogenic induction: the dawn of a new era for ischemia therapy and tissue regeneration

E Hadjipanayi, AF Schilling - Organogenesis, 2013 - Taylor & Francis
… as spheroids, exhibited improved therapeutic efficacy.Citation 27 In this model, spheroid
cultures were more effective in pre-conditioning … endothelial cell tubule formation and directional …