… subunits are members of the larger NF-κB/Rel family of This understanding of the sites and
… for the kinase (s) scription, our view of the role of NF-κB in immune and responsible for IκB …

… of IκB. The key regulatory step in this pathway involves activation of a high molecular weight
IκB kinase (IKK) complex, whose catalysis is generally carried out by a heterodimeric kinase …

… control of IκB phosphorylation in response to all other NF-κB activating stimuli rests on the
shoulders of the IκB kinase (… Once it became clear that the key step in NF-κB activation was IκB …

… IKKβ turned out to be the crucial kinase of the IKK-signalosome for activation of NF-κB by
most inflammatory stimuli, which is considered the classical or canonical pathway of NF-κB …

… NF-κB activation depends on phosphorylation-induced proteolysis of inhibitory IκB molecules
and NF-κB … diverse signaling pathways that activate NF-κB converge on IκB kinases (IKK), …

… A pivotal regulator of all inducible NF-κB signaling pathways is the IκB kinase (IKK)
complex that consists of two kinases (IKKα and IKKβ) and a regulatory subunit named NF-κB …

… IκB kinase‐mediated activation of NF‐κB is differentially regulated by IKKα and IKKβ. Both
kinases … identity), and contain an N‐terminal kinase domain, a dimerization domain and a C‐…

… from the ubiquitination-inducible IκB kinase complex (18). Because the IκB kinase is unrelated
to MAP or Jun kinases, IKK represents a completely novel kinase pathway. The work to …

… kappa B (NF-κB) by inflammatory cytokines requires the successive action of NF-κB–inducing
kinase (NIK) and IκB kinase–α (IKK-α). A widely expressed protein kinase was identified …

… Activators of the IKK complex include mitogen-activated protein kinase kinase kinases (MAP3Ks)
such as MEKK1, MEKK3 and TAK1 and it represents a convergence point for …