… , mainly by proinflammatory cytokines, a multisubunit protein kinase, the IκB kinase (IKK),
is … for NF-κB activation in response to proinflammatory stimuli. The second catalytic subunit, …

… Exposure to pro-inflammatory cytokines (TNFα and IL-1) results in activation of signaling …
ionizing radiation, a multisubunit complex, the IκB kinase complex (IKK) is rapidly activated and …

… of known kinases, but none of these kinases could match the requirements for an IκB
kinase. In a 1996 study, biochemical characterization revealed that the actual IκB kinase is …

… members of the inhibitor of κB (IκB) kinase (IKK) family. The … signaling in response to multiple
proinflammatory stimuli such as TNF and TLR ligands. IKKα and IKKβ are Ser/Thr kinases …

… Here we have analyzed the contribution of the IKK/IκB/NF-κB signaling pathway to
endothelial protein expression upon inflammatory stimulation. We used a retroviral transduction …

… pro-inflammatory signalling, we investigated the effect of AMPK activation on pro-inflammatory
signalling … We also examined basal pro-inflammatory signalling pathway status in adipose …

… NF-κB signaling pathways is the IκB kinase (IKK) complex that consists of two kinases (IKKα
and … identified a unique inhibitor of pro-inflammatory NF-κB signaling, an unforeseen role for …

… Proinflammatory cytokines induce the activation of NF-κB in both transient and persistent …
NF-κB p105 is a target of IκB kinases and controls signal induction of Bcl-3-p50 complexes. …

… of Akt in the signalling pathway through which TNFα leads to … IκB degradation and NF-κB
activation rely on the IκB kinase (… for IκB degradation in response to proinflammatory stimuli, …

… cells, vice versa immunologically relevant signaling proteins contribute to the rewiring of …
–associated factor 6, which participates in proinflammatory signaling downstream of IL-1– …