… A critical step in the activation of NF-κB is the phosphorylation of IκBs by the IκB kinase (IKK) …
We conclude that while IKKγ is a stoichiometric component of the IKK complex, obligatory …

… Composed of two serine‐threonine kinases (IKKα and IKKβ) and the … various IκB and NF‐κB
proteins, as well as of other substrates. Since the discovery of the IKK complex components …

… Most of the diverse signaling pathways that activate NF-κB converge on IκB kinases (IKK), …
of structure and function of the regular stoichiometric components, the regulatory transient …

… Its catalytic subunits, IKKα and IKKβ, require association with the regulatory IKKγ (NEMO)
component to gain full basal and inducible kinase activity. However, the oligomeric …

… These metrics are regularly updated to reflect usage leading up to the last few days. … it can
activate both IκB kinases in vivo ( 16). Other as yet identified components of the IKK complex …

… NF-κB activation due to the lack of the IκB kinase (IKKγ) protein. Ectopic expression of
IKKγ … protein kinase JNK is blocked in 1.3E2 cells, suggesting that an upstream component …

… structures representing all three components are now available… fascinating kinase complex
known as the IKK (IκB kinase) … as in p50 allows RelB to form a regular dimer, it would suggest …

… These data suggest that NIK is a specific kinase regulating p100 processing and explain why
… NF-κB p105 is a target of IκB kinases and controls signal induction of Bcl-3-p50 complexes. …

… component of NF-κB signaling in HT-29 cells, we next delivered two proximal kinases involved
in IκB … for various times and IKK kinase activity was measured in vitro using GST-IκB (1–54…

… When associated with NF-κB, IκBα also binds and inhibits the catalytic domain of protein
kinase A (… The regular structure of the ankyrin stacks, with residues responsible for interprotein …