… TTV ORF2 protein could … ORF2 protein did not alter the level of NF-κB expression but
prevented the p50 and p65 subunits from entering the nucleus due to the inhibition of IκBα protein …

… protein in HEV pathogenesis. First, it promotes cell survival and proliferation through extracellular
regulated kinase (… , ORF2, and ORF3 proteins, among which the ORF3 protein appears …

… by the inhibitor of NF-κB (IκB) protein. IκB phosphorylation by the IκB kinase (IKK) complex is
… ΔORF3 could express the ORF2 protein without expressing the ORF3 protein (Figure S3A). …

… and activation of the IκB kinases (IKKs) which … ORF2 protein to inhibit the cellular NF-κB
activity. In human hepatoma cells, ORF2 protein could directly associate with the F-box protein …

… at least six distinct proteins: p48, NTPase, p22, VPg, 3CLpro, and RdRP. ORF2 encodes the
major capsid protein VP1, and ORF3 encodes the minor capsid protein VP2, locating inside …

… Here, we report that the full length HEV ORF2 protein (FL ORF2) inhibits RIG-I signaling in
… IFN-β promoter and Renilla luciferase under thymidine kinase promoter. A synthetic 27 bp …

… kinase (IKK) complex phosphorylates specific serine within the … in IκB proteins correlated
with increased NF-κB activity. … No significant differences were seen in the ORF2 protein …

… (a) RGS16 protein expression levels in empty vector transfectants (Mock) and PCV2 ORF1-,
ORF2- or ORF3-expressing PK15 cells (ORF1, ORF2, ORF3). Total cell lysates from each …

… ORF2 encodes the capsid protein, the major structural protein of virions. ORF3 encodes a …
Activation of RLR and TLR signaling leads to activation of two IκB kinase (IKK)-related kinases…

… kinase complex (IKK), which in turn phosphorylates IκB, targeting it for ubiquitination and
degradation, allowing NF-κB proteins (… Herpesviruses encode multiple proteins that function in …