Adding a LAMA to ICS/LABA therapy: a meta-analysis of triple combination therapy in COPD

L Calzetta, M Cazzola, MG Matera, P Rogliani - Chest, 2019 - Elsevier
treatment recommendations, 10 the aim of this meta-analysis was to compare the pooled
efficacy and cardiovascular safety data from trials of ICS/LABA/LAMA with ICS/LABAtherapy in …

Evaluating triple ICS/LABA/LAMA therapies for COPD patients: a network meta-analysis of ETHOS, KRONOS, IMPACT, and TRILOGY studies

L Calzetta, BL Ritondo, P de Marco… - Expert Review of …, 2021 - Taylor & Francis
… The aim of this study was a quantitative synthesis by considering the studies that directly
compared triple ICS/LABA/LAMA vs. either dual LABA/LAMA or ICS/LABA therapies

Comparative efficacy of inhaled medications (ICS/LABA, LAMA, LAMA/LABA and SAMA) for COPD: a systematic review and network meta-analysis

MIA Aziz, LE Tan, DBC Wu, F Pearce… - … journal of chronic …, 2018 - Taylor & Francis
… , LAMA/LABAs and ICS/LABAs using published … /LABAs and ICS/LABAs led to a greater
improvement in trough FEV 1 compared with placebo and SAMA monotherapy. All LAMA/LABAs

Impact of ICS/LABA and LABA/LAMA FDCs on functional and clinical outcomes in COPD: a network meta-analysis

L Calzetta, F Di Marco, F Blasi, M Cazzola… - Pulmonary …, 2019 - Elsevier
… the currently available dual therapies in patients with moderate-to-severe COPD. In particular,
this study aimed to compare and rank LABA/LAMA FDCs and ICS/LABA FDCs on trough …

LABA/LAMA combinations versus LAMA monotherapy or LABA/ICS in COPD: a systematic review and meta-analysis

GJ Rodrigo, D Price, A Anzueto, D Singh… - … journal of chronic …, 2017 - Taylor & Francis
… with commonly used COPD treatments. The objective of this analysis was to compare the
efficacy and safety of LABA/LAMA with LAMA or LABA/inhaled corticosteroid (ICS) in adults …

Efficacy of ICS versus non-ICS combination therapy in COPD: a meta-analysis of randomised controlled trials

Y Ding, L Sun, Y Wang, J Zhang… - International Journal of …, 2022 - Taylor & Francis
… The results of our meta-analysis showed a significant benefit of ICS/LABA … Based on the
results of this meta-analysis, ICS therapy is an important part of the therapeutic armamentarium …

Long‐acting muscarinic antagonist (LAMA) plus long‐acting beta‐agonist (LABA) versus LABA plus inhaled corticosteroid (ICS) for stable chronic obstructive …

N Horita, A Goto, Y Shibata, E Ota… - Cochrane Database …, 2017 - cochranelibrary.com
… (ICS). When two classes of medications are required, LAMA plus LABA (LAMA+LABA) and
LABA plus ICS (LABA+ICS) … LABA+ICS, which is compatible with our analysis (Nannini 2012). …

Triple therapy (ICS/LABA/LAMA) in COPD: time for a reappraisal

L Vanfleteren, LM Fabbri, A Papi… - … journal of chronic …, 2018 - Taylor & Francis
… of these triple therapies, discusses the role of ICS in patients with … ” (ICS/LAMA/LABA) therapy
vs LAMA, ICS/LABA, and LAMA/LABA combinations, and summarizes studies in which ICS/…

… ‐acting muscarinic antagonist+ long‐acting beta agonist versus long‐acting beta agonist+ inhaled corticosteroid for COPD: a systematic review and metaanalysis

N Horita, N Miyazawa, K Tomaru, M Inoue… - …, 2015 - Wiley Online Library
meta-analysis were original trials written in English comparing the impact of LAMA + LABA
and LABA + ICS for … Compared with LABA + ICS, LAMA + LABA led to significantly greater …

Triple therapy versus single and dual long-acting bronchodilator therapy in COPD: a systematic review and meta-analysis

M Cazzola, P Rogliani, L Calzetta… - European Respiratory …, 2018 - Eur Respiratory Soc
… options (particularly in patients at low risk of exacerbations), we performed a systematic
review and a meta-analysis to determine the effect of ICS/LABA/LAMA combination …