Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease
I Nakao, S Kanaji, S Ohta, H Matsushita… - The Journal of …, 2008 - journals.aai.org
… In this study, we identified the SLC26A4 gene as an IL-13-inducible gene, using a microarray
approach, and found that pendrin is highly expressed at the apical membrane of bronchial …
approach, and found that pendrin is highly expressed at the apical membrane of bronchial …
The role of pendrin in the airways: links with asthma and COPD
K Izuhara, S Suzuki, C Nofziger, M Ogawa… - The Role of Pendrin in …, 2017 - Springer
… After pendrin was identified as a bronchial asthma-related molecule downstream of IL-4 and
IL-13 signals, our comprehension about its involvement in pulmonary dysfunction has been …
IL-13 signals, our comprehension about its involvement in pulmonary dysfunction has been …
… anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma …
Y Nakagami, S Favoreto, G Zhen, SW Park… - The Journal of …, 2008 - journals.aai.org
… that pendrin plays a role in allergic airway disease and in regulation of ASL thickness.
Pendrin-deficient mice had less allergen-induced airway … To identify effects of pendrin on ASL, we …
Pendrin-deficient mice had less allergen-induced airway … To identify effects of pendrin on ASL, we …
Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma
J Park, HJ Lee, D Song, M Gi, S Jo, D Jeon… - Journal of Allergy and …, 2019 - jacionline.org
… These observations indicate that pendrin is a novel target for allergic asthma. In this study,
we identified a novel pendrin inhibitor, YS-01 (2-(4-(tert-butyl)phenyl)-4-(thiophen-2-…
we identified a novel pendrin inhibitor, YS-01 (2-(4-(tert-butyl)phenyl)-4-(thiophen-2-…
Pendrin function in airway epithelia
C Nofziger, S Dossena, S Suzuki, K Izuhara… - Cellular Physiology and …, 2011 - karger.com
… , Fukuda T, Green ED, Izuhara K: Identification of pendrin as a common mediator for mucus
production in bronchial asthma and chronic obstructive pulmonary disease. J Immunol 2008;…
production in bronchial asthma and chronic obstructive pulmonary disease. J Immunol 2008;…
Identification of allelic variants of pendrin (SLC26A4) with loss and gain of function
S Dossena, A Bizhanova, C Nofziger… - Cellular physiology and …, 2011 - karger.com
… , Fukuda T, Green ED, Izuhara K: Identification of pendrin as a common mediator for mucus
production in bronchial asthma and chronic obstructive pulmonary disease. J Immunol 2008;…
production in bronchial asthma and chronic obstructive pulmonary disease. J Immunol 2008;…
Expression of pendrin and periostin in allergic rhinitis and chronic rhinosinusitis
A Ishida, N Ohta, Y Suzuki, S Kakehata… - Allergology …, 2012 - jstage.jst.go.jp
… Background: Pendrin and periostin are newly identified … of pendrin and periostin in sinonasal
tissue of patients with allergic rhinitis, chronic rhinosinusitis, and aspirin-induced asthma. …
tissue of patients with allergic rhinitis, chronic rhinosinusitis, and aspirin-induced asthma. …
The mechanism of mucus production in bronchial asthma
K Izuhara, S Ohta, H Shiraishi, S Suzuki… - Current medicinal …, 2009 - ingentaconnect.com
… Pendrin is a multispanning transmembrane protein and acts as an anion transporter. Pendrin
was originally identified … Alternatively, the main pathological roles of pendrin in asthma may …
was originally identified … Alternatively, the main pathological roles of pendrin in asthma may …
STAT6 links IL‐4/IL‐13 stimulation with pendrin expression in asthma and chronic obstructive pulmonary disease
C Nofziger, V Vezzoli, S Dossena… - Clinical …, 2011 - Wiley Online Library
… as in mouse models of bronchial asthma and COPD. There is … feature observed in bronchial
asthma and COPD and is a … leukocytes; 37 have been identified, although some of their …
asthma and COPD and is a … leukocytes; 37 have been identified, although some of their …
The significance of hypothiocyanite production via the pendrin/DUOX/peroxidase pathway in the pathogenesis of asthma
K Izuhara, S Suzuki, M Ogawa… - Oxidative medicine …, 2017 - Wiley Online Library
… To identify a novel mediator involved in asthma pathogenesis downstream of the IL-13
signals, we and others previously used DNA microarray to search for IL-13-induced molecules in …
signals, we and others previously used DNA microarray to search for IL-13-induced molecules in …
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