… idiopathic pulmonary fibrosis and we’re in the process of studying the relationship between
cigarette smoking, excess MUCB production, and the development of pulmonary fibrosis. In …

… Notably, the short telomere phenotype in peripheral blood mononuclear cells (PBMCs) is
not limited to patients with loss of function rare variants in telomerase complex genes. …

… a complex genetic disorder (189), suggesting that the different histological types of idiopathic
… These findings highlight the complex nature of IPF and suggest that while a susceptibility …

… -causing heterozygous mutations in TERT (encoding telomerase reverse transcriptase)
and TERC (encoding the RNA component of the telomerase complex). Notably, …

… -third of the inherent individual risk of disease 23 . Age is the … Indeed, IPF is a complex disorder
resulting from interactions … , suggesting a complex deregulation of downstream genes 54 . …

… AECs in pulmonary fibrosis comes from studies in the past decade linking genetic mutations
… explants usually show end-stage fibrosis, and it is difficult to determine the primary inciting …

… Genetic predisposition to IPF is evident from its familial aggregation and the fact that pulmonary
fibrosis develops in several rare genetic disorders… complex disease with multiple genetic …

… and sporadic pulmonary fibrosis has arisen from the recent description of germline
mutations in the genes hTERT and hTR, which are associated with the telomerase complex [32]. …

… 9-DPP9) for the development of the disease. Both the GWAS established the role of the
promoter of MUC5B gene as a risk factor of disease and characterized other common variants …

… diseases (ILDs) are a heterogeneous collection of over 100 different diseases, all characterized
by pulmonary fibrosis. … Unlike cystic fibrosis, the genetics of IPF are complex. There is …