Idiopathic pulmonary fibrosis: Molecular mechanisms and potential treatment approaches
DS Glass, D Grossfeld, HA Renna, P Agarwala… - Respiratory …, 2020 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease with high mortality that
commonly occurs in middle-aged and older adults. IPF, characterized by a decline in lung
function, often manifests as exertional dyspnea and cough. Symptoms result from a fibrotic
process driven by alveolar epithelial cells that leads to increased migration, proliferation,
and differentiation of lung fibroblasts. Ultimately, the differentiation of fibroblasts into
myofibroblasts, which synthesize excessive amounts of extracellular matrix proteins …
commonly occurs in middle-aged and older adults. IPF, characterized by a decline in lung
function, often manifests as exertional dyspnea and cough. Symptoms result from a fibrotic
process driven by alveolar epithelial cells that leads to increased migration, proliferation,
and differentiation of lung fibroblasts. Ultimately, the differentiation of fibroblasts into
myofibroblasts, which synthesize excessive amounts of extracellular matrix proteins …