… IDO is up-regulated in response to inflammatory conditions as a novel marker of immune
activation in early atherosclerosis. Besides, IDO and the IDO-related pathway are important …

… that IDO is involved in TEC damage [36]. The JAK-STAT1 pathway is required for IDO activation
… IDO suppression lowered the expression of p53 and p21 in T-cells in mixed lymphocyte …

… kynurenine pathway are obvious. A most important aspect is certainly the impact of pro-inflammatory
pathways on the activation of IDO-… tryptophan via the kynurenine pathway in a broad …

… Taken together, these data suggest that even in the absence of functional IDO, kynurenine
pathways enzymes, if activated by IFN-γ in the presence of an appropriate precursor, catalyze …

… Activation of the IDO-KYN-AhR pathway. Inflammaging stimulates the expression of IDO1
which catabolizes L-tryptophan to kynurenine (KYN) and its metabolites. A depletion of L-…

… It has been proposed that the IDO-kynurenine pathway can serve as a negative feedback …
of the kynurenine pathway in granulocyte activation. A burst of IFN-γ-dependent IDO activation …

… will therefore be on regulation of TDO and IDO and the flux of Trp down the pathway. …
Unlike TDO, IDO in rats or mice does not require heme for its activation nor is it inducible by …

… -2 in activating the kynurenine pathway. Although inhibition of the PD-1/PD-L1 axis has
proved very valuable, some melanomas and models have proved resistant. Tumor growth and …

… 1) tryptophan conversion to kynurenines is activated in DCs by … not only IDO, but also
the complete kynurenine pathway is … inability of IDO to produce the first metabolite, l-kynurenine, …

… The stimulation of immune system cells activates several enzymes in the kynurenine pathway
which are relevant to the control of leukocyte populations and the balance between pro- …