Subcutaneous injection of interferon gamma therapy could be useful for anti–IFN-γ autoantibody associated disseminated nontuberculous mycobacterial infection

M Harada, K Furuhashi, M Karayama, Y Suzuki… - Journal of Infection and …, 2021 - Elsevier
… levels of IFN-γ in the patient's plasma had been retained after the incubation with rh–IFNγ.
Thus, we treated the patient with a subcutaneous injection of exogenous recombinant IFN-γ

Oral administration of IFN-α is superior to subcutaneous administration of IFN-α in the suppression of chronic relapsing experimental autoimmune encephalomyelitis

SA Brod, M Khan - Journal of autoimmunity, 1996 - Elsevier
… Spleen and lymph node cells from mock fed, untreated or mIFN-α fed or sc injected animals
were cultured with Con A (2.5 µg/ml) or MT at 10 µg/ml at 1×106 cells/ml in 75 cm2 tissue …

Pharmacokinetics and biological activity in subcutaneous long-term administration of recombinant interferon-γ in cancer patients

W Digel, G Zahn, G Heinzel, F Porzsolt - Cancer Immunology …, 1991 - Springer
… , or 0.5 mg/m 2) in two or three injections per week for up to 180 days. The most common …
sc injection of rHuIFN7 were approximately proportional to the dose administered: the injection

Subcutaneous interferoninjections in patients with multiple sclerosis initiate inflammatory skin reactions by local chemokine induction

M Buttmann, M Goebeler, A Toksoy, S Schmid… - Journal of …, 2005 - Elsevier
… skin reactions frequently observed in MS patients treated by sc IFNinjections. In skin
biopsies obtained from MS patients 24 h after sc injection of IFN-β, we detected strong CXCL10 …

No Evidence of IFN-γ Increase in the Serum of HIV-Positive and Healthy Subjects after Subcutaneous Injection of a Non-Fermented Viscum album L. Extract

M Stoss, RW Gorter - Natural immunity, 1999 - karger.com
… In conclusion, no increase in serum IFN-Á levels was thus observed after repeated subcutaneous
injections of VaQuFrF in our trial. The baseline IFN-Á concentration in 2 HIVpositive …

Adjuvant effects of IL-1β, IL-2, IL-8, IL-15, IFN-α, IFN-γ TGF-β4 and lymphotactin on DNA vaccination against Eimeria acervulina

W Min, HS Lillehoj, J Burnside, KC Weining, P Staeheli… - Vaccine, 2001 - Elsevier
… Chickens were given two subcutaneous injections with 50 μg of the pcDNA3-1E vaccine
plus a cytokine expression plasmid 2 weeks apart and challenged with Eimeria acervulina 1 …

IFN-γ-dependent inhibition of tumor angiogenesis by tumor-infiltrating CD4+ T cells requires tumor responsiveness to IFN-γ

GL Beatty, Y Paterson - The Journal of Immunology, 2001 - journals.aai.org
… On day −1, immunized mice were treated with ip injection of either saline (▪) or 500 μg of
anti-IFN-γ XMG1.2 (□). Mice were then sc injected with 1 × 105 CT26 on day 0 with CT26 tumor …

Experimental gene therapy against subcutaneously implanted glioma with a herpes simplex virus-defective vector expressing interferon-γ

H Kanno, S Hattori, H Sato, H Murata, FH Huang… - Cancer Gene …, 1999 - nature.com
… Alternatively, if tumor cells undergo ex vivo IFNgene transfer with an HSV-defective vector
and then the IFN- gene-transfected cells are injected sc as a tumor vaccine, this method may …

Pharmacokinetics of recombinant murine interferon-γ in mice

I RUTENFRANZ, H KIRCHNER - Journal of interferon research, 1988 - liebertpub.com
… To determine the pharmacokinetics after the sc (Fig. 3) and … in the case of sc injection. After
im application the maximum … was cal¬ culated with 42 min for sc injection and 49 min for im …

Interferon gamma-1b: a review of its pharmacology and therapeutic potential in chronic granulomatous disease

PA Todd, KL Goa - Drugs, 1992 - Springer
… After randomisation and stratification patients received IFNγ-1b or placebo by subcutaneous
injection … Induction of phagocyte cytochrome b heavy chain gene expression by interferon γ. …