… The diagnosis of multiple sclerosis is based on dissemination in time and space. Before …
The present meta-analysis (13,467 patients) shows that the diagnostic specificity of OCB drops …

… The purpose of this report is to validate the quantitation of the de novo CNS IgG synthesis
rate in MS patients, using an empirical formula based on physiologic principles governing the …

… Objectives– We study the power of IgG synthesis value as a marker of disease activity in
multiple sclerosis (MS). Material and methods– Link index was calculated in 202 MS patients. …

… IgG synthesized, one MS and two OND had oligoclones. … IgG synthesis as calculated by
our formula and CSF oligoclones in all patients with a normal BBB, and also in the MS patients …

… IgG synthesis is a key biological feature of multiple sclerosis (MS). A growing body of evidence
suggests that intrathecal IgG … transiently depressed IgG synthesis in only 4 patients out of …

… Fifty-nine multiple sclerosis patients were investigated with regard to blood-brain barrier
function by determining the CSF-protein and the CSF/S albumin ratio. Abnormal values were …

… Markers of intrathecal IgG synthesis, such as the IgG index, are useful in … Q IgG to Q Lim
was also calculated as another indicator of intrathecal IgG synthesis, different from the IgG index. …

… work of Tourtellotte on intracerebral IgG synthesis in MS and to extend these studies to
examine the influence of relapse on IgG synthesis. We have also studied patients with SSPE, a …

… remitting multiple sclerosis or clinically isolated syndrome. Patients with intrathecal IgG synthesis
were found … Meaning Intrathecal IgG synthesis is associated with disability worsening in …

… cells from patients with multiple sclerosis synthesized IgG and IgA in vitro, The synthesized
IgG bad an oligoclonal distribution and showed the same eleitrophoretic pattern as the IgG of …