… studies showed downstaging with pCR of more than 15% after preoperative CRT compared
with approximately 5% after RT alone. This randomized phase III study … this randomized trial …

… In this article, we propose a Bayesian phase II/III treatment evaluation strategy. Patients are
randomized between E and S throughout. In phase 11, the decision of whether to stop early, …

… In contrast with previous studies that compared placebo with a titrated dosage of active
drug… 9 this phase III study was a true dosage-ranging study, enabling evaluation of benefit/risk …

Purpose This phase III international study compared the efficacy and safety of a combination
of pegylated liposomal doxorubicin (PLD) plus bortezomib with bortezomib monotherapy in …

… This prospective phase III study aims to compare the efficacy, safety and toxicity of GT in
a randomized setting with standard antimicrobial treatment in 74 patients with febrile …

… study defined the minimally effective dose, phase II studies suggested that perampanel doses
higher than the 8 mg/day dosing assessed in this study … completed randomized phase III …

… Also in agreement are the VTE data observed in the randomized phase III study by
Kanget al 33 in patients with advanced or metastatic gastric cancer who were treated with …

… Overall Study Design BFR14 is an open-label, multicentric, randomized phase III clinical
trial randomizing treatment interruption versus maintenance after 1 year in patients with …

… have also been initiated, mainly in Japan, and two phase II studies reported high response
… in PC, the present randomized phase III study (GEST [Gemcitabine and S-1 Trial] study) was …

… in phase I/II studies. The combination of irinotecan and S-1 (IRI-S) is also active against
advanced gastric cancer. This study … tolerated, it did not show significant superiority in this study. …