… , resulting in down-regulation of NF-κB signaling (Lobry et al. 2007). This indicates that the
IKK complex can behave both as a positive and a negative regulator of the cascade. Other …

… of a catalytically active complex comparable in size to the large IKK complex, yet the activity
of this … Hence, PDK1 seems to serve a central role in TCR signaling, bringing several critical …

… An X‐ray structure of the central region, associated with a fragment of the viral IKK activating
… Nuclear factor‐қB essential modulator has a central role in polyubiquitin‐mediated IKK …

… factor, NF-κB, plays a central role in the regulation of many genes … In summary, activation of
the IKK complex via interaction of … Another contribution to down-regulation of this pathway is …

… antibody against IKK-α, we purify the IKK complex to … We find that IKK is composed of similar
amounts of IKK-α, IKK-β and … of IKK-γ, while its central region probably interacts with IKK-β. …

… deal about the mechanisms regulating IKK complex activity; … induced activation and down
regulation of IKK remains distant [… catalytic domain, a central leucine zipper motif through which …

… Many studies have supported the assumption that one major cytoplasmic IKK complex exists,
… Nevertheless, the presence of a ubiquitin binding domain in NEMO, the central regulator of …

… regulators of NF-κB activation and identified an additional regulatory protein ELKS in the IKK
complex. … component of the IKK complex identified by our group. ELKS was discovered by …

… that TRAF3 modulates activity of the IKK complex through regulation of NIK protein, which
is … Sex-chromosome dosage (SCD) effects on human gene expression are central to the …

… crucial roles in the regulation of numerous biological processes … is triggered that targets
the IKK complex such that one of its … Whereas the presence of a G:C or C:G bp at this central …