… heterodimeric kinase consisting of IKKα and IKKβ subunits. This review describes the
identification of proteins in the IKK complex, and the regulation and physiological functions of IKK. …

… The IκB kinase (IKK) complex is the signal integration hub for NF‐κB activation. … kinases
(IKKα and IKKβ) and the regulatory subunit NEMO (also known as IKKγ), the IKK complex …

… , IKK-α and IKK-β, are protein kinases whose … IKK-α, we purify the IKK complex to homogeneity
from human cell lines. We find that IKK is composed of similar amounts of IKK-α, IKK-β …

… form a functional IκB kinase. We demonstrate that the functional IKK complex contains both
IKKα and IKKβ and that both kinases make essential contributions to IκB phosphorylation and …

… The two kinase subunits of the IKK complex, IKKα and IKKβ, have been purified and
cloned … phosphorylate the IκB inhibitors following biochemical purification of the complex (Mercurio …

… ent in 293 cells where IKKα-associated kinase activity of the IKK complex, we refer to it as …
We envision the IKK complex to contain two protein kinase subunits tation is IKKα with a …

… Using solely IKKα, IKKβ, and IKKγ, we could reconstitute a complex whose apparent …
IKK complex. We conclude that while IKKγ is a stoichiometric component of the IKK complex, …

… IκB phosphorylation in response to all other NF-κB activating stimuli rests on the shoulders of
the IκB kinase (IKK) complex… Gel filtration experiments suggest that IKK is a protein complex…

… is the IκB kinase (IKK) complex that consists of two kinases (… Genetic analysis of the IKK
complex has identified two … To better understand the mechanisms that regulate IKK complex …

… The IκB kinase (IKK) complex, containing the catalytic kinases IKKα and IKKβ and the
regulatory non-enzymatic scaffold protein NEMO (NF-κB essential modifier; also called IKKγ) …