… However, the distribution of IKZF1 mutation in Chinese children with B-cell ALL (B-ALL) has
… the clinical and genetic characteristics of Chinese B-ALL children with IKZF1 mutation in our …

… We report the first Chinese patient with a mutated IKZF1 gene studied by WES. The mutant
gene c.500A>G has previously been reported in 3 patients [3]. The similarities between these …

… , somatic mutations in IKZF1 have … IKZF1 mutations have been identified in patients with
a B cell immune deficiency mimicking common variable immunodeficiency. These mutations …

… variants of IKZF1 mutations (haploinsufficiency and dominant negative) clinical phenotypes
… -phenotype correlation and clinical manifestations in patients with IKZF1 mutations. The …

… between IKZF1 polymorphisms and SLE susceptibility, cytokine levels, and clinical characteristics
… [11–13] In this study, we observed that IKZF1 is one of SLE susceptibility genes in the …

… gene expression patterns following IKZF1 mutations, we then performed bulk RNA-Seq of
IKZF1 G158S, N159S and N159Y mutant … Unsupervised clustering of mutant and WT IKZF1 …

… the features of IKZF1 MUT AML, we compared the baseline characteristics of the IKZF1 MUT
and IKZF1 … ELN 2017 prognostic stratification predicted the clinical outcome of AML patients …

… in B cell–deficient patients in this study, together with a previous report, provides genetic
evidence for a heterozygous IKZF1 mutation causing dysgammaglobulinemia with or without …

… Here we report coding germline IKZF1 variation in familial … IKZF1 function and drug
responsiveness of leukemic cells. These results identify IKZF1 as a leukemia predisposition gene, …

… We report a novel IKZF1 variant (p.His195Arg) in a family. This variant is likely to be loss-of-…
immune defect and clinical presentation in patients with IKZF1 mutations remains unknown. …