… To our surprise, we failed to detect any biological activity of IL-1 in serum or urine of …
Reductions were statistically significant compared with vehicle with IL-1Ra 1 and 5 mg/kg/h (…

… significant body of experimental evidence has implicated the proinflammatory cytokine IL-1
in the pathogenesis of RA. … binding of IL-1 and IL-1 , thereby reducing the biological effects of …

… IL- 1 genes suggests duplication of a common gene some 350 million years ago. Before this
common IL-1 … because IL-l and FGF share significant amino acid homologies, lack a signal …

… The cytokine now known as IL-1 was originally described as biological activities in cell …
The significance of this finding as part of a protective host response remains unclear. …

… IL-1 receptors are more selectively expressed in different cell types. Two receptor antagonists,
IL-1Ra and IL-1F5, inhibit the biologic … cell lineages, the biologic significance of which is …

… Of the three members of the IL‐1 family (IL‐1α, IL‐1β, IL‐1 Ra), IL‐1β has the lowest affinity
for … MAPK and NF‐κB pathways can block the biological effect of IL‐1 and of other cytokines. …

… The objectives of this review are tosummarize recent information on additional structural
variants of IL-1Ra, therole of IL-1Ra in biologic processes, and the effects of endogenous …

… The biological significance of the IL-1 locus genetic association with erosive RA remains
unclear. … for an IL-1 haplotype which, by multiple pathways, determines different activities on the …

… Since IL-1 is found in … biological significance of the "catabolic" properties of IL-1 in the
pathogenesis of joint disease is likely considerable. Another aspect of the biological effects of IL-1 …

… IL-1 ra in PLGA and we studied the biological activity of IL-1 ra released from PLGA IL-1
ra … Treatment with IL-1 ra or PLGA IL-1 ra at 20 ng/ml resulted in a significant reduction in …