The opportunities and challenges of developing imaging biomarkers to study lung function and disease

DP Schuster - American journal of respiratory and critical care …, 2007 - atsjournals.org
lung volume, whether a reliable association can be demonstrated between the imaging
biomarker … be daunting if not impossible for costly biomarkers such as imaging. Therefore, to take …

Standardized airway wall thickness Pi10 from routine CT scans of COPD patients as imaging biomarker for disease severity, lung function decline, and mortality

K Kahnert, RA Jörres, HU Kauczor… - Therapeutic …, 2023 - journals.sagepub.com
… Previous studies addressing the association between Pi10 and lung function decline were
… In the present study, we also evaluated the lung function decline in association with Pi10 …

Early imaging biomarkers of lung cancer, COPD and coronary artery disease in the general population: rationale and design of the ImaLife (Imaging in Lifelines) Study

C Xia, M Rook, GJ Pelgrim, G Sidorenkov… - European journal of …, 2020 - Springer
… The cohort invited for lung function testing was unselected (primarily based on scheduling
of lung function test slots). However, there was a number of exclusion criteria for lung function

MRI and CT lung biomarkers: Towards an in vivo understanding of lung biomechanics

HM Young, RL Eddy, G Parraga - Clinical Biomechanics, 2019 - Elsevier
… The primary clinical biomarker of lung function is the spirometry measurement of forced …
and discuss imaging methods required to generate imaging biomarkers of lung biomechanics, …

Radiomics and its emerging role in lung cancer research, imaging biomarkers and clinical management: State of the art

G Lee, HY Lee, H Park, ML Schiebler… - European journal of …, 2017 - Elsevier
… With the development of functional imaging modalities we now have the ability to study the
microenvironment of lung cancer and its genomic instability. Radiomics is defined as the use …

Predicting Postoperative Lung Function in Patients with Lung Cancer Using Imaging Biomarkers

OB Kwon, HU Lee, HE Park, JY Choi, JW Kim, SH Lee… - Diseases, 2024 - mdpi.com
imaging biomarkers. This study aimed to predict postoperative lung function with imaging
biomarkers… A retrospective analysis of 79 patients with lung cancer who had undergone lung

Comparison of the quantitative CT imaging biomarkers of idiopathic pulmonary fibrosis at baseline and early change with an interval of 7 months

HJ Kim, MS Brown, D Chong, DW Gjertson, P Lu… - Academic radiology, 2015 - Elsevier
… This indicates that high kurtosis is associated with mild disease based on lung function. …
(indicating that patients with relatively good lung function are associated with small extent of …

Using imaging as a biomarker for asthma

A Trivedi, C Hall, EA Hoffman, JC Woods… - Journal of Allergy and …, 2017 - Elsevier
… been used to assess regional lung function. Hyperpolarized 3 He … in lung ventilation after
bronchodilator therapy. Further studies are needed to evaluate the optimal imaging biomarker

[HTML][HTML] Mechanism and non-mechanism based imaging biomarkers for assessing biological response to treatment in non-small cell lung cancer

A Weller, MER O'Brien, M Ahmed, S Popat… - European journal of …, 2016 - Elsevier
… than is available on anatomical imaging alone. Use of these biomarkers, or other rational …
emission tomography and magnetic resonance imaging biomarker indices is examined and …

Noninvasive imaging biomarker identifies small airway damage in severe chronic obstructive pulmonary disease

DM Vasilescu, FJ Martinez, N Marchetti… - American journal of …, 2019 - atsjournals.org
… termed “functional small airways disease” (fSAD) (11). Longitudinal imaging studies suggest
lung function decline even among at-risk individuals initially without airflow obstruction (12). …