COVID-19: imbalanced immune responses and potential immunotherapies

B Xie, J Zhang, Y Li, S Yuan, Y Shang - Frontiers in Immunology, 2021 - frontiersin.org
… , apart from direct viral toxicity, immune dysregulation serves as an … been conducted to
evaluate immune-related therapies for … In this review, we discuss the role of immune responses in …

Inflammaging, an imbalanced immune response that needs to be restored for cancer prevention and treatment in the elderly

J Serrano-López, B Martín-Antonio - Cells, 2021 - mdpi.com
… Inflammaging is related to an imbalanced immune response … that administers ex vivo
expanded immune cells in the patient. … Herein, we review subsets of immune cells with a pertinent …

Imbalanced immune response of T-cell and B-cell subsets in patients with moderate and severe COVID-19

A Golovkin, O Kalinina, V Bezrukikh, A Aquino… - Viruses, 2021 - mdpi.com
… an imbalance within almost all circulating memory Th subsets during acute COVID-19
and showed that altered Tfh polarization led to a dysregulated humoral immune response. …

COVID-19: imbalanced cell-mediated immune response drives to immunopathology

J Wang, Q Li, YW Qiu, H Lu - Emerging Microbes & Infections, 2022 - Taylor & Francis
… However, the triggers and consequences of a disruption to immune system homeostasis …
and systemic immune progression from an imbalance in cell-mediated immune responses to …

Imbalanced immune responses involving inflammatory molecules and immune-related pathways in the lung of acute and subchronic arsenic-exposed mice

J Li, L Zhao, Y Zhang, W Li, X Duan, J Chen… - Environmental …, 2017 - Elsevier
… multiple pulmonary immune responses involving inflammatory … with the imbalanced redox
status and activation of immune-… of imbalanced immune responses are still under elucidation. …

Aging, imbalanced inflammation and viral infection

DR Goldstein - Virulence, 2010 - Taylor & Francis
… to be due to declining immune responses. However, our work indicates that older people
may succumb to viral infection due to exaggerated immune responses as aged mice produce …

Pathogenesis and outcome of VA1 astrovirus infection in the human brain are defined by disruption of neural functions and imbalanced host immune responses

OA Maximova, ML Weller, T Krogmann… - PLoS …, 2023 - journals.plos.org
… We show that the innate, but not adaptive immune response … an imbalance of innate and
adaptive immune responses to AstV … is associated with imbalanced host defense responses, …

Imbalanced immune homeostasis in immune thrombocytopenia

K Yazdanbakhsh - Seminars in hematology, 2016 - Elsevier
… of the adaptive immune system are likely to be due to dysregulated innate immune responses
and cytokine imbalance. Despite normalization of regulatory imbalance following treatment…

The role of immune response in the pathogenesis of idiopathic pulmonary fibrosis: far beyond the Th1/Th2 imbalance

P Spagnolo, R Tonelli, AV Samarelli… - Expert Opinion on …, 2022 - Taylor & Francis
… In this review, we explored the potential role of the innate and adaptive immune response
in the pathogenesis and progression of IPF focusing on the evidence derived from human and …

Integrative single-cell RNA sequencing and metabolomics decipher the imbalanced lipid-metabolism in maladaptive immune responses during sepsis

H She, L Tan, Y Wang, Y Du, Y Zhou, J Zhang… - Frontiers in …, 2023 - frontiersin.org
… the immune cells. An alteration in the immunometabolism can trigger the disturbance of
immune response … , studies that sequence pooled populations of immune cells, rather than each …