Synthesis and Pharmacological Evaluation of Some Hydrazone and Azole Hybrids Bearing 1h-Benzo [D] Imidazole-2-Thiolmoiety as Potential Anticancer G …
S Padma, S Padma, GK GaddamKiranmai… - … of Some Hydrazone … - papers.ssrn.com
… core inserted between two flanking hydrazone/azole units to … analysis and apoptosis assay
were performed to analyze the … Also, in silico ADME-Tox predictions were carried out for drug…
were performed to analyze the … Also, in silico ADME-Tox predictions were carried out for drug…
Synthesis, computational analysis, antimicrobial, antioxidant, trypan blue exclusion assay, β-hematin assay and anti-inflammatory studies of some hydrazones (part-I)
SN Mali, A Pandey - Current Computer-Aided Drug Design, 2023 - ingentaconnect.com
… Thus, this analysis suggested the anti-inflammatory potential of our hydrazones (Table 4). …
QikProp calculated results for ADME were retained within acceptable ranges. Normal mode …
QikProp calculated results for ADME were retained within acceptable ranges. Normal mode …
Synthesis, molecular modeling investigation, molecular dynamic and ADME prediction of some novel Mannich bases derived from 1, 2, 4-triazole, and assessment of …
S Manap, H Medetalibeyoğlu, A Kılıç… - Journal of …, 2023 - Taylor & Francis
… ADME/T analysis of the studied compounds (M1-5) was performed for this examination. With
this analysis, the … In addition, we used ADME-Tox and molecular docking to evaluate the …
this analysis, the … In addition, we used ADME-Tox and molecular docking to evaluate the …
[PDF][PDF] Quinolone-Pyrazinamide Derivatives: Synthesis, characterisation, in silico ADME analysis and in vitro biological evaluation against Mycobacterium tuberculosis.
KG Rukweza - 2023 - core.ac.uk
… The SwissADME analysis of these compounds indicated poor solubility in aqueous media, …
3.8af showed acceptable physicochemical properties and ADME parameters. No PAINs (Pan-…
3.8af showed acceptable physicochemical properties and ADME parameters. No PAINs (Pan-…
Quantitative structural activity relationship of hydrazide derivatives of loratadine: a combined density functional theory and in silico study
OF Akinyele, IA Alimi - Journal of Chemical Society of …, 2019 - journals.chemsociety.org.ng
… In this study, we report the simulation of hydrazide and hydrazone derivatives of Loratadine.
… A set of in vitro ADME/Toxicity screens were used for the analysis of the ADME and overt …
… A set of in vitro ADME/Toxicity screens were used for the analysis of the ADME and overt …
[HTML][HTML] In-silico and in-vitro functional validation of imidazole derivatives as potential sirtuin inhibitor
UMR Dindi, SP Sadiq, S Al-Ghamdi, NA Alrudian… - Frontiers in …, 2023 - frontiersin.org
… ADME analysis ADME properties were analyzed for all the ligands that were investigated
in this study. The results of the ADME analysis showed effective absorption, solubility, and the …
in this study. The results of the ADME analysis showed effective absorption, solubility, and the …
Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1 H-imidazol-5-yl)-1 H-indole-5-carboxamides, low-basicity 5-HT …
… discovered indole–imidazole scaffold were synthesized and … 5 included the assessment of
ADME-Tox parameters by using … cyanide 3-chlorophenyl-hydrazone (CCCP) was used at 10 …
ADME-Tox parameters by using … cyanide 3-chlorophenyl-hydrazone (CCCP) was used at 10 …
Combined experimental and theoretical studies of the structure-antiradical activity relationship of heterocyclic hydrazone compounds
… In summary, from the obtained results of the antiradical evaluation by DPPH, ABTS, and …
all the investigated hydrazones have antiradical activity in all the tested method. The imidazole …
all the investigated hydrazones have antiradical activity in all the tested method. The imidazole …
Tailoring of some novel bis-hydrazone metal chelates, spectral based characterization and DFT calculations for pharmaceutical applications and in-silico treatments …
HA Qasem, MR Aouad, HA Al-Abdulkarim… - Journal of Molecular …, 2022 - Elsevier
… As a result, we used Swiss-ADME connection to pass onto the numerous Swiss Drug Design
… Overall, it is anticipated that the information gleaned from this analysis will be useful in the …
… Overall, it is anticipated that the information gleaned from this analysis will be useful in the …
[HTML][HTML] Design, synthesis, biological assessment and in silico ADME prediction of new 2-(4-(methylsulfonyl) phenyl) benzimidazoles as selective cyclooxygenase-2 …
MAS Badawy, EKA Abdelall, ELN EL-Shaymaa… - RSC …, 2021 - pubs.rsc.org
… The in silico analysis of the subsequent pharmacokinetic parameters was also carried
out using pkCMS online software, the predicted ADME parameters' outcomes are depicted (see …
out using pkCMS online software, the predicted ADME parameters' outcomes are depicted (see …