… containing 4, 5-disubstituted thiazole as potential antibiofilm, anti-inflammatory and antioxidant agents: Green synthesis, molecular docking and ADME analysis

D Bhosale, A Narale, P Hadimani, M Kokane… - Journal of Molecular …, 2024 - Elsevier
ADME, we computed and examined several physical characteristics and pharmaceutically
significant attributes for ADME … and elimination (ADME) factors have been analyzed to predict …

Synthesis, characterization, thermal properties, antimicrobial evaluation, ADMET study, and molecular docking simulation of new mono Cu (II) and Zn (II) complexes …

A Ragab, YA Ammar, A Ezzat, AM Mahmoud… - Computers in Biology …, 2022 - Elsevier
… synthesized by two different methods based on hydrazone derivatives 2 and 3. Additionally,
… elemental analysis, FT-IR, mass spectra, and 1 H/ 13 C NMR. Thermogravimetric analysis

Design, synthesis, and evaluation of a new series of hydrazones as small-molecule akt inhibitors for NSCLC therapy

B Erdönmez, MD Altıntop, G Akalın Çiftçi… - ACS …, 2023 - ACS Publications
… the 1H-imidazole core … analysis of A549 cells treated with IC 50 values of compounds 3a,
3e, 3g, 3i, and cisplatin. At least 10,000 cells were analyzed per sample, and quadrant analysis

Design, synthesis, molecular modeling, DFT, ADME and biological evaluation studies of some new 1, 3, 4-oxadiazole linked benzimidazoles as anticancer agents and …

U Acar Çevik, I Celik, A Işık, I Ahmad… - Journal of …, 2023 - Taylor & Francis
ADME properties of the potential aromatase inhibitor compound 5a were analyzed by … in
phase studies without a drug molecule due to poor ADME properties. Making some theoretical …

Novel thiomorpholine tethered isatin hydrazones as potential inhibitors of resistant Mycobacterium tuberculosis

S Karunanidhi, B Chandrasekaran, R Karpoormath… - Bioorganic …, 2021 - Elsevier
… synthesized and characterized novel isatin hydrazones 4(ao) and their … Further, molecular
docking, ADME pharmacokinetic and molecular … In summary, isatin hydrazones 4(ao) and their …

An Insight into the Biological Properties of Imidazole‐Based Schiff Bases: A Review

AK Gopalakrishnan, SA Angamaly… - …, 2021 - Wiley Online Library
… Molecular docking, Lipinski's rule of five, and ADME predictions confirmed the vigorous …
-based compounds for conceivable clinical application in the analysis and treatment of …

In silico-Based Structural Prediction, Molecular Docking and ADMET Analysis of Novel Imidazo-Quinoline Derivatives as Pf Purine Nucleoside Phosphorylase …

C Mallick, M Mishra, V Asati, V Kashaw… - Current Signal …, 2023 - ingentaconnect.com
… available methods take a longer time for ADME prediction. Due to the poor pharmacokinetics
… by the oxygen atom substituted in the imidazole ring. The three aromatic rings presented in …

Imidazole as a promising medicinal scaffold: current status and future direction

SS Alghamdi, RS Suliman, K Almutairi… - Drug Design …, 2021 - Taylor & Francis
ADME analysis was calculated using the SwissADME webserver. To determine whether the
imidazole … , we have selected the most potent imidazole derivatives that demonstrated high …

Repurposing of benzimidazole scaffolds for HER2 positive breast cancer therapy: An in-silico approach

S Jubie, U Durai, S Latha… - … : Current Drug Abuse …, 2021 - ingentaconnect.com
… ABZ), being another derivative of benzimidazole category, became more popular in the
year … zole, we decided to synthesize benzimidazole hydrazones and evaluate their anti-breast …

[HTML][HTML] Computational Drug Designing, Synthesis, Characterization and Anti-bacterial Activity Evaluation of Some Mixed Ligand–Metal Complexes of 2 …

T Khan, S Zehra, U Fatima, N Mishra, R Lawrence… - Chemistry Africa, 2023 - Springer
… 2-hydroxybenzaldehyde thiosemicarbazone) as primary ligand and imidazole (im), pyridine
(py) … The mixed ligand complexes having imidazole as secondary ligand displayed relatively …