[HTML][HTML] COVID-19 vaccines: modes of immune activation and future challenges

JR Teijaro, DL Farber - Nature Reviews Immunology, 2021 - nature.com
… approved vaccines trigger innate immunity to promote durable … Severe COVID-19 involving
acute respiratory distress … mobilize innate and adaptive immune responses, implications for …

[HTML][HTML] Identification of immune activation markers in the early onset of COVID-19 infection

JJ Kovarik, AK Kämpf, F Gasser, AN Herdina… - Frontiers in cellular …, 2021 - frontiersin.org
… into the specific systemic immune response of the host, early after COVID-19 infection and
ultimately might help to develop innovative therapeutic strategies against COVID-19 infection. …

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19

…, K D'Andrea, UPenn COVID Processing Unit… - Science …, 2021 - science.org
… patients with COVID-19, recovered adult COVID-19 individuals, and … immune landscape in
pediatric COVID-19 was similar to adults, MIS-C represented an exacerbated T cell activation

The role of immune activation and antigen persistence in acute and long COVID

S Opsteen, JK Files, T Fram… - Journal of Investigative …, 2023 - journals.sagepub.com
… long COVID symptoms. These data suggest a portion of long COVID symptoms may be due
to chronic immune activation … the COVID-19 literature to date detailing acute COVID-19 and …

[HTML][HTML] Immune cartography of macrophage activation syndrome in the COVID-19 era

D McGonagle, AV Ramanan… - Nature Reviews …, 2021 - nature.com
… Conversely, at the other boundary, immune hypersensitivity with gain of immune function in
… patients with COVID-19 pneumonia, which cripples primary type I interferon immunity and …

[HTML][HTML] Endothelial cell infection and dysfunction, immune activation in severe COVID-19

Z Qin, F Liu, R Blair, C Wang, H Yang, J Mudd… - Theranostics, 2021 - ncbi.nlm.nih.gov
… , and immune activation are observed in COVID-19 patients. … associated with immune
activation remain to be determined. … (K18) mice, a severe COVID-19 mouse model, as well as …

[HTML][HTML] Prolonged adaptive immune activation in COVID-19: implications for maintenance of long-term immunity?

PA Mudd, KE Remy - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
COVID-19 vaccine trials. The importance of these studies to provide context for the interpretation
of immune responses generated by participants in COVID-19 … to existing COVID-19

[HTML][HTML] Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

FWJ Chioh, SW Fong, BE Young, KX Wu, A Siau… - Elife, 2021 - elifesciences.org
… recovery from COVID-19 form our impetus to investigate the impact of COVID-19 on vascular
… a biomarker of vascular injury, in COVID-19 convalescents compared to healthy controls. In …

Is adipose tissue a reservoir for viral spread, immune activation, and cytokine amplification in coronavirus disease 2019?

PMD Ryan, NM Caplice - Obesity, 2020 - Wiley Online Library
… We present a rationale for testing this concept in patients with COVID-19 through prospective
studies of individuals with and without obesity with accessible AT and plasma to determine …

T‐cell recovery and evidence of persistent immune activation 12 months after severe COVID19

P Taeschler, S Adamo, Y Deng, C Cervia… - Allergy, 2022 - Wiley Online Library
… To investigate alterations of the immune system after acute COVID-19, we performed mass
… after SARS-CoV-2 infection in a cohort of 173 COVID-19 patients and 42 healthy controls. …