Immune checkpoint inhibitors for cancer therapy: clinical efficacy and safety

SC Azoury, DM Straughan… - Current cancer drug …, 2015 - ingentaconnect.com
A major breakthrough in cancer immunotherapy was the discovery of immune checkpoint
proteins, which function to effectively inhibit the immune system through various mechanisms. …

Efficacy and safety of immune checkpoint inhibitors in non-small cell lung cancer

S Wang, J Hao, H Wang, Y Fang, L Tan - Oncoimmunology, 2018 - Taylor & Francis
Immune checkpoint inhibitors (ICIs) are new therapeutic strategies for non-small cell lung
cancer (NSCLC). We aimed to quantitatively evaluate the efficacy and safety of ICIs in NSCLC. …

Comparative safety of immune checkpoint inhibitors in cancer: systematic review and network meta-analysis

C Xu, YP Chen, XJ Du, JQ Liu, CL Huang, L Chen… - Bmj, 2018 - bmj.com
… a safety ranking of immune checkpoint inhibitor (ICI) drugs for treatment of cancer. DESIGN
safety of immune checkpoint inhibitor (ICI) drugs in the treatment of patients with cancer …

[HTML][HTML] Immune-related adverse events and anti-tumor efficacy of immune checkpoint inhibitors

S Das, DB Johnson - Journal for immunotherapy of cancer, 2019 - Springer
Although immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for
patients with many advanced malignancies, only 15–60% of patients respond, leaving a …

A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant

…, Immune Checkpoint Inhibitors in Solid Organ … - Kidney international, 2021 - Elsevier
Immune checkpoint inhibitors (ICIs) revolutionized … safety, we sought to identify the incidence,
timing, and risk factors for acute graft rejection following ICI therapy. For the clinical efficacy

The clinical value of combination of immune checkpoint inhibitors in cancer patients: a meta‐analysis of efficacy and safety

Y Wu, H Shi, M Jiang, M Qiu, K Jia… - … Journal of Cancer, 2017 - Wiley Online Library
The use of immune checkpoint inhibitors (ICIs) in combination therapy is an emerging trend
in tumor immunology. However, the value of combination immunotherapy remains …

Efficacy and safety associated with immune checkpoint inhibitors in unresectable hepatocellular carcinoma: a meta-analysis

AA Jácome, ACG Castro, JPS Vasconcelos… - JAMA network …, 2021 - jamanetwork.com
… This systematic review examined the efficacy and safety associated with immune checkpoint
inhibitors (ICIs) in patients with HCC, finding 3 randomized clinical trials eligible for meta-…

Efficacy and safety of immune checkpoint inhibitors in advanced gastric or gastroesophageal junction cancer: a systematic review and meta-analysis

C Chen, F Zhang, N Zhou, YM Gu, YT Zhang… - …, 2019 - Taylor & Francis
Background: Immune checkpoint inhibitors (ICI) have shown promising prospects in
gastroesophageal junction (G/GEJ) cancer immunotherapy, many clinical trials have been carried …

[HTML][HTML] The efficacy and safety of immune checkpoint inhibitors in patients with cancer and preexisting autoimmune disease

H Tang, J Zhou, C Bai - Frontiers in oncology, 2021 - frontiersin.org
Immune checkpoint inhibitor (ICI) is a revolutionary breakthrough in the field of cancer treatment.
Because of dysregulated activation of the immune … AID, the safety and efficacy of ICIs in …

[HTML][HTML] Effectiveness and safety of immune checkpoint inhibitors for patients with advanced non small-cell lung cancer in real-world: review and meta-analysis

M Mencoboni, M Ceppi, M Bruzzone, P Taveggia… - Cancers, 2021 - mdpi.com
… In this review and meta-analysis we evaluated the benefits of immune checkpoint inhibitors,
especially the PD-1/PD-L1 inhibitors nivolumab, pembrolizumab and atezolizumab, as a …