Antibodies to oxidized LDL and LDL-containing immune complexes as risk factors for coronary artery disease in diabetes mellitus

MF Lopes-Virella, G Virella, TJ Orchard, S Koskinen… - Clinical …, 1999 - Elsevier
… are likely to emerge in patients with antibodies to oxLDL, … of oxLDL-IC (immune complexes)
to an IDDM patient population in which we have shown that decreased antibodies to oxLDL

Oxidized LDL–anti-oxidized LDL immune complexes and diabetic nephropathy

D Atchley, M Lopes-Virella, D Zheng, D Kenny… - Diabetologia, 2002 - Springer
Oxidized LDL is immunogenic and immune complexes formed by oxidized LDL and cor…
and/or characteristics of oxidized LDL- antioxidized LDL complexes correlated with the degree of …

Influence of age and sex on levels of anti-oxidized LDL antibodies and anti-LDL immune complexes in the general population

FJ Tinahones, JM Gómez-Zumaquero… - Journal of lipid …, 2005 - ASBMB
… Levels of immune complexes were significantly higher (P = 0.05) in persons aged 5–15 …
, oxidized LDL autoantibodies have been found both free and forming immune complexes ( …

High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes

MF Lopes-Virella, NL Baker, KJ Hunt, TJ Lyons… - Diabetes …, 2012 - Am Diabetes Assoc
OBJECTIVE To determine whether immunocomplexes (ICs) containing advanced glycation
end product (AGE)–LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the …

Positive correlation between in vivo oxidized LDL and LDL immune complexes

H Bing, J Wang, C Zhang, H Cai - Clinical biochemistry, 2004 - Elsevier
LDL might trigger an immune response leading to the production of autoantibodies and
subsequently to the formation of immune complexes (IC). … or soluble LDL-containing IC (LDL-IC) …

Oxidized LDL and AGE-LDL in circulating immune complexes strongly predict progression of carotid artery IMT in type 1 diabetes

KJ Hunt, N Baker, P Cleary, JY Backlund, T Lyons… - Atherosclerosis, 2013 - Elsevier
… between circulating concentrations of IC of oxidized LDL (oxLDL-IC), malondialdehyde-LDL
(MDA-LDL-IC) and advanced glycation end products-LDL (AGE-LDL-IC) and progression of …

Oxidized LDL immune complexes and coronary artery calcification in type 1 diabetes

MF Lopes-Virella, NL Baker, KJ Hunt, J Lachin… - Atherosclerosis, 2011 - Elsevier
OxLDL-IC measurement We measured oxLDL by first precipitating circulating immune
complexes … antibody from modified LDL, as previously described [16], [22]. The concentration of …

Oxidized LDL immune complexes and oxidized LDL differentially affect the expression of genes involved with inflammation and survival in human U937 monocytic …

SM Hammad, WO Twal, JL Barth, KJ Smith, AF Saad… - Atherosclerosis, 2009 - Elsevier
… Immobilization of oxLDL-IC by attachment to … oxLDL-IC as a form of immobilized immune
complexes to stimulate macrophages. Insoluble oxLDL-IC were prepared with human oxLDL

Differential trafficking of oxidized LDL and oxidized LDL immune complexes in macrophages: impact on oxidative stress

MM Al Gadban, KJ Smith, F Soodavar, C Piansay… - PloS one, 2010 - journals.plos.org
… Our present data demonstrated that cells treated with oxLDL exhibited reduced … compared
to oxLDL-IC, KLH-IC immune complexes. Cells treated with immune complexes maintained …

Levels of oxidized LDL and advanced glycation end products–modified LDL in circulating immune complexes are strongly associated with increased levels of carotid …

MF Lopes-Virella, KJ Hunt, NL Baker, J Lachin… - Diabetes, 2011 - Am Diabetes Assoc
… against modified LDL is the formation of immune complexes (… both oxLDL and oxLDL
antibodies have been found (16,17). … react with oxLDL, malondialdehyde-modified LDL (MDA-LDL)…