The ups and downs of STAT3 function: too much, too little and human immune dysregulation
… the notion that STAT3 function needed to be regulated to maintain immune homeostasis. As
… errors in STAT3, we will review our current understanding of STAT3 function, mechanisms …
… errors in STAT3, we will review our current understanding of STAT3 function, mechanisms …
STAT3: too much may be worse than not enough!
E Haddad - Blood, The Journal of the American Society of …, 2015 - ashpublications.org
… -cell function, STAT3 GOF is responsible for both immune dysregulation and immune deficiency…
The clinical phenotype of STAT3 GOF-induced immune dysregulation is very diverse and …
The clinical phenotype of STAT3 GOF-induced immune dysregulation is very diverse and …
Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations
… Genetic variants in proteins involved in cytokine signaling are now recognized as a cause
of overwhelming human immune dysregulation. Autosomal dominant gain-of-function (GOF) …
of overwhelming human immune dysregulation. Autosomal dominant gain-of-function (GOF) …
STAT3 gain-of-function syndrome
… of additional patients with STAT3 GOF syndrome and studies of the mechanisms behind
this disease have enhanced our understanding of the immune dysregulation found in these …
this disease have enhanced our understanding of the immune dysregulation found in these …
The ying and yang of STAT3 in human disease
… Heterozgyous, germline, loss-of-function mutations in STAT3 lead to the primary immune …
The immune dysregulation in STAT3 GOF leads to recurrent and/or severe infections in …
The immune dysregulation in STAT3 GOF leads to recurrent and/or severe infections in …
[PDF][PDF] STAT1/STAT3 Gain of Function and Mechanisms of Immune Dysregulation.
A Kıykım - Turkish Journal of Immunology, 2024 - jag.journalagent.com
… Interestingly, most of our findings on the functions of STAT3 … respect to the state of immune
dysregulation seen in most patients… about immune system dysregulation in STAT1 and STAT3 …
dysregulation seen in most patients… about immune system dysregulation in STAT1 and STAT3 …
[HTML][HTML] Multisystem autoimmune disease caused by increased STAT3 phosphorylation and dysregulated gene expression
F Todaro, N Tamassia, M Pinelli, D Moratto… - …, 2019 - ncbi.nlm.nih.gov
… immune response (eg SOCS3 and SNBO2), we performed a ChIP assay in EBV-transformed
cells from the patient with STAT3 … two healthy donors or the STAT3 gain-of-function (GOF) …
cells from the patient with STAT3 … two healthy donors or the STAT3 gain-of-function (GOF) …
Partial growth hormone insensitivity and dysregulatory immune disease associated with de novo germline activating STAT3 mutations
M Gutiérrez, P Scaglia, A Keselman, L Martucci… - Molecular and cellular …, 2018 - Elsevier
… and immune dysregulation. The functional analyses showed that both variants were gain-of-…
stature and immune dysregulation due to activating germline STAT3 mutations identified by …
stature and immune dysregulation due to activating germline STAT3 mutations identified by …
Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation–polyendocrinopathy–enteropathy–X-linked–like syndrome
G Uzel, EP Sampaio, MG Lawrence, AP Hsu… - Journal of allergy and …, 2013 - Elsevier
… Syndromes in which pronounced immune dysregulation is … poor skin and gut barrier function
and are receiving aggressive … IL-21, cytokines that signal through both STAT3 and STAT1. …
and are receiving aggressive … IL-21, cytokines that signal through both STAT3 and STAT1. …
Immune deficiency vs. immune excess in inflammatory bowel diseases—STAT3 as a rheo-STAT of intestinal homeostasis
M Leppkes, MF Neurath, M Herrmann… - Journal of Leucocyte …, 2016 - academic.oup.com
… gene, STAT3, on various cell types and cellular functions. We show how alterations in certain
components of the intestinal immune … A dysregulation of the STAT3 pathway in T cells has …
components of the intestinal immune … A dysregulation of the STAT3 pathway in T cells has …
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