… the notion that STAT3 function needed to be regulated to maintain immune homeostasis. As
… errors in STAT3, we will review our current understanding of STAT3 function, mechanisms …

… -cell function, STAT3 GOF is responsible for both immune dysregulation and immune deficiency…
The clinical phenotype of STAT3 GOF-induced immune dysregulation is very diverse and …

… Genetic variants in proteins involved in cytokine signaling are now recognized as a cause
of overwhelming human immune dysregulation. Autosomal dominant gain-of-function (GOF) …

… of additional patients with STAT3 GOF syndrome and studies of the mechanisms behind
this disease have enhanced our understanding of the immune dysregulation found in these …

… Heterozgyous, germline, loss-of-function mutations in STAT3 lead to the primary immune …
The immune dysregulation in STAT3 GOF leads to recurrent and/or severe infections in …

… Interestingly, most of our findings on the functions of STAT3 … respect to the state of immune
dysregulation seen in most patients… about immune system dysregulation in STAT1 and STAT3 …

… immune response (eg SOCS3 and SNBO2), we performed a ChIP assay in EBV-transformed
cells from the patient with STAT3 … two healthy donors or the STAT3 gain-of-function (GOF) …

… and immune dysregulation. The functional analyses showed that both variants were gain-of-…
stature and immune dysregulation due to activating germline STAT3 mutations identified by …

… Syndromes in which pronounced immune dysregulation is … poor skin and gut barrier function
and are receiving aggressive … IL-21, cytokines that signal through both STAT3 and STAT1. …

… gene, STAT3, on various cell types and cellular functions. We show how alterations in certain
components of the intestinal immune … A dysregulation of the STAT3 pathway in T cells has …