Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects
L Burdelya, M Kujawski, G Niu, B Zhong… - The Journal of …, 2005 - journals.aai.org
… Stat3 activity in melanoma negatively regulates infiltration of diverse immune effector cells
and that targeting Stat3 in tumor cells … recruiting immune cells and eliciting innate immune cell-…
and that targeting Stat3 in tumor cells … recruiting immune cells and eliciting innate immune cell-…
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
H Yu, M Kortylewski, D Pardoll - Nature reviews immunology, 2007 - nature.com
… STAT3 activity propagates from tumour cells to immune cells in the tumour microenvironment,
thereby mediating immune … cells and regulatory T cells, and by activating effector cells …
thereby mediating immune … cells and regulatory T cells, and by activating effector cells …
STAT3, a master regulator of anti-tumor immune response
C Rébé, F Ghiringhelli - Cancers, 2019 - mdpi.com
… T-cell effector functions such as CD8 + T-cell, γδ T-cell generations … activities of TAMs correlate
with over-activated STAT3 … of TAMs STAT3 activity can enhance rat immune response to …
with over-activated STAT3 … of TAMs STAT3 activity can enhance rat immune response to …
STAT3 signaling in immunity
EJ Hillmer, H Zhang, HS Li, SS Watowich - Cytokine & growth factor …, 2016 - Elsevier
… of STAT3 AD-HIES (eg, impaired skin and lung immunity) was … cells require the combined
activity of cytokines from STAT3-dependent, IL-17-producing CD4 + T lymphocytes (Th17 cells) …
activity of cytokines from STAT3-dependent, IL-17-producing CD4 + T lymphocytes (Th17 cells) …
A critical role for Stat3 signaling in immune tolerance
F Cheng, HW Wang, A Cuenca, M Huang, T Ghansah… - Immunity, 2003 - cell.com
… , increased Stat3 activity in APCs resulted in impaired T cell … of T cell tolerance occurs in mice
with an intact Stat3 signaling in … PEM trigger effector function of clonotypic CD4 + T cells, as …
with an intact Stat3 signaling in … PEM trigger effector function of clonotypic CD4 + T cells, as …
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
T Wang, G Niu, M Kortylewski, L Burdelya, K Shain… - Nature medicine, 2004 - nature.com
… We propose that tumor Stat-3 activity can mediate immune evasion by blocking both the …
of the antigen processing and presentation machinery critical for effector T cells 32,33,34 , our …
of the antigen processing and presentation machinery critical for effector T cells 32,33,34 , our …
STAT3 signaling contributes to the high effector activities of interleukin‐15‐derived dendritic cells
S Okada, S Han, ES Patel, LJ Yang… - Immunology and Cell …, 2015 - Wiley Online Library
… the activities of IL-15 DCs in the initiation and maintenance of immune effector responses. …
MAPK) and STAT3 activities that underlie the strong immune effector functions of IL-15 DCs. …
MAPK) and STAT3 activities that underlie the strong immune effector functions of IL-15 DCs. …
Therapeutically exploiting STAT3 activity in cancer—using tissue repair as a road map
… -dependent feedforward signalling loops further fuel tumour progression by collectively
antagonizing the recruitment of immune effectors into the tumour bed and impairing …
antagonizing the recruitment of immune effectors into the tumour bed and impairing …
STAT3: a target to enhance antitumor immune response
H Lee, SK Pal, K Reckamp, RA Figlin, H Yu - Cancer Immunology and …, 2011 - Springer
… Increased Stat3 activity in tumor-associated immune cells promotes immunosuppressive …
for the terminal differentiation of Th17 cell into effector cells in a Stat3-dependent fashion (…
for the terminal differentiation of Th17 cell into effector cells in a Stat3-dependent fashion (…
STAT3 activation-induced fatty acid oxidation in CD8+ T effector cells is critical for obesity-promoted breast tumor growth
… obesity negatively impacts antitumor immune responses remains largely … STAT3 in CD8 +
T effector cells is critical for obesity-associated breast tumor progression. Ablating T cell Stat3 …
T effector cells is critical for obesity-associated breast tumor progression. Ablating T cell Stat3 …
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