… STAT3 pathway also becomes constitutively active in diverse tumor-infiltrating immune cells,
markedly impairing their antitumor effector … anti-tumor and immune-modulatory activities. …

… Finally, we discuss the evolution of the suppressive activity of STAT3 and the therapeutic
potential of STAT3 inhibitors in host defense against viral infections and IFN-I-associated …

… STAT3 may be activated as a downstream effector of … STAT3 activity appears to mediate
immune evasion by tumours, … Constitutive STAT3 activity in tumours increases the production …

… cell lines when cocultured with T cells. Dexamethasone can suppress T cell exhaustion by
decreasing the activity of two immune … translocation of GR/STAT3 complex. These findings …

… Poor chemokine-mediated trafficking of effector cells and the … that a T-cell hyporesponsive
state consistent with anergy … (69), and increase the activity of the innate immune system (70). It …

… Stat3 activity promotes tumor cell growth and survival, tumor angiogenesis and metastasis,
and induces tumor immune … -induced, Stat3 ptyr705 phosphorylation, acting as an effector of …

… expression, we speculated that TLR4 might be involved in the regulation of STAT3 activity
in … The activity of STAT3, the key effector molecule of IL-10 signal, was also remarkably …

… Many lines of evidence intimately link STAT3 aberrant activity with the development and …
Additionally, IL-6-activated STAT3 is implicated in mediating the escape of T effector …

… Despite significant infiltration into tumors, the effector function … STAT3, and because gliomas
express high levels of S100B, a RAGE ligand, we hypothesized that MP/MG STAT3 activity …

… We have generated mice with a cell type-specific disruption of the Stat3 gene in … immune
response toward the Th1 type and develop chronic enterocolitis with age. Taken together, Stat3 …