… in combination with other effector molecules). … Stat3 activity. One of these mechanisms was
revealed after it was shown that activated Stat3 prevented apoptosis of human myeloma cells …

… cells differentiate into effector cells that have been historically classified into two lineages,
TH1 and TH2, based on their cytokine secretion and immune … enhanced activity of STAT3 in …

… , it appears that HDAC activities are essential in activating or … inhibition modifies the
acetylation state of signaling proteins … on gene expression can be cell-state dependent. LAQ824 …

… penetration of functional immune effector cells (Mitchell … Stat3 activity both in vitro and in
vivo. Here, we demonstrate that factors secreted by tumor cells result in the upregulation of Stat3 …

… Furthermore, aberrant STAT3 activity was demonstrated to suppress the expression of
MHC … effector cells or used in combination with other agonists to elicit anti-tumor response. …

… Infiltration of CD3 + T cells and Granzyme B + effector cells was significantly increased in
MT/Shc 2F/2F tumours (P<0.0001 by Mann–Whitney U-test) (Fig. 1e and Supplementary Fig. 2a…

… Cytokines can also modulate the effector functions of immune cells in a STAT3-dependent …
STAT3 activity promotes an oncogenic transcription profile in tumor cells that supports cell …

… in immune effector cells (but not melanoma tumor cells) is … P-STAT3 in both melanoma
cells and immune effector cells is … Stat3 activity in melanoma cells affects migration of immune …

… in Th17 cells, we tested their immunosuppressive activity on effector CD4 … Stat3 dimerization
or the silencing of Stat3 with specific siRNA abolish the Entpd1 and Nt5e promoter activities …

… with STAT3 activity. Finally, we propose that the STAT3-mediated anti-inflammatory signaling
pathway can operate in multiple … effector cells and nitric oxide-mediated antitumor effects. …