Mechanisms of immune evasion and current status of checkpoint inhibitors in non‐small cell lung cancer
… with advanced non-small cell lung cancer (NSCLC) without … the methods of immune evasion
employed by NSCLC which … (2) describe the mechanisms of immune evasion (3) summarize …
employed by NSCLC which … (2) describe the mechanisms of immune evasion (3) summarize …
Immune escape mechanisms in non small cell lung cancer
A Anichini, VE Perotti, F Sgambelluri, R Mortarini - Cancers, 2020 - mdpi.com
… by immune checkpoint blockade (ICB). In this review, we will discuss the most recent evidence
on immune … , and the contribution of immune evasion to resistance to ICB in lung cancer. …
on immune … , and the contribution of immune evasion to resistance to ICB in lung cancer. …
Determinants of immunological evasion and immunocheckpoint inhibition response in non-small cell lung cancer: the genetic front
M Saigi, JJ Alburquerque-Bejar, M Sanchez-Cespedes - Oncogene, 2019 - nature.com
… In this paper we describe what is currently known about the dynamic interaction between
the cancer cell and the immune system during carcinogenesis, with a particular focus on the …
the cancer cell and the immune system during carcinogenesis, with a particular focus on the …
[HTML][HTML] Epigenetic therapy ties MYC depletion to reversing immune evasion and treating lung cancer
MJ Topper, M Vaz, KB Chiappinelli, CEDS Shields… - Cell, 2017 - cell.com
… The development of effective therapeutic approaches for patients with lung cancer, the
world’s leading cause of cancer-related death, is a critical medical need. The advent of immune …
world’s leading cause of cancer-related death, is a critical medical need. The advent of immune …
Evasion of innate immunity contributes to small cell lung cancer progression and metastasis
M Zhu, Y Huang, ME Bender, L Girard, R Kollipara… - Cancer research, 2021 - AACR
… In our preclinical models, restoration of NKG2D ligand expression restored immune … immune
evasion mechanism by SCLCs as well as a roadmap to new immune treatment strategies. …
evasion mechanism by SCLCs as well as a roadmap to new immune treatment strategies. …
Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms
… genomic regions, such as endogenous retroviral elements and introns, in immune-cold
subtypes. Further, we linked immune evasion with LAG-3 via STK11 mutation-dependent HNF1A …
subtypes. Further, we linked immune evasion with LAG-3 via STK11 mutation-dependent HNF1A …
Immune evasion before tumour invasion in early lung squamous carcinogenesis
… the immune response. These findings highlight the need to develop immune biomarkers for
… chemopreventive approaches for individuals who are at high risk of developing lung cancer. …
… chemopreventive approaches for individuals who are at high risk of developing lung cancer. …
Spatial architecture of myeloid and T cells orchestrates immune evasion and clinical outcome in lung cancer
… This study provides novel insights into the spatial organization of the lung cancer TME in
the context of tumor immunogenicity, tumor heterogeneity, and cancer evolution. Pairing the …
the context of tumor immunogenicity, tumor heterogeneity, and cancer evolution. Pairing the …
Epithelial–mesenchymal transition and immune evasion during lung cancer progression: The chicken or the egg?
I Datar, KA Schalper - Clinical Cancer Research, 2016 - AACR
… Immune evasion is required for tumor progression and is … immune response and upregulation
of immune-suppressive signals. The coexistence of EMT and adaptive immune evasion …
of immune-suppressive signals. The coexistence of EMT and adaptive immune evasion …
Circular RNA hsa_circ_0000190 facilitates the tumorigenesis and immune evasion by upregulating the expression of soluble PD-L1 in non-small-cell lung cancer
YH Luo, YP Yang, CS Chien, AA Yarmishyn… - International Journal of …, 2021 - mdpi.com
… Additionally, the combined effects of immune checkpoint inhibitors and circRNAs inhibitors …
against the immune evasion of lung cancer cells and to strengthen the efficacy of lung cancer …
against the immune evasion of lung cancer cells and to strengthen the efficacy of lung cancer …
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