Analyzing and validating the prognostic value and mechanism of colon cancer immune microenvironment

X Wang, J Duanmu, X Fu, T Li, Q Jiang - Journal of Translational Medicine, 2020 - Springer
… essential genes for constructing colon cancer immune microenvironment, we performed
WGCNA and got 8 hub genes which were in the module correlated with immune capacity. Finally…

The colorectal cancer immune microenvironment and approach to immunotherapies

M Koi, JM Carethers - Future Oncology, 2017 - Taylor & Francis
… II and III colon cancer patients ( Figure 1 A) [Citation91–93]. The results of these studies
showed that co-inoculation of irradiated, viable tumor cells from stage II colon cancer exhibiting …

The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints

NJ Llosa, M Cruise, A Tam, EC Wicks… - Cancer discovery, 2015 - AACR
… using antibody blockade of immune checkpoints. We demonstrate here that the immune
microenvironment of DNA repair–deficient MSI colorectal cancer contains a strong Th1 and CTL …

Differential immune signatures in the tumor microenvironment are associated with colon cancer racial disparities

T Curran, Z Sun, B Gerry, VJ Findlay… - Cancer …, 2021 - Wiley Online Library
… Our evaluation of the tumor immune microenvironment revealed … microenvironment, possibly
suggesting a more favorable immune environment for CD8-mediated antitumor immunity in …

[PDF][PDF] The role of tumor microenvironment and immune response in colorectal cancer development and prognosis

M Wozniakova, J Skarda, M Raska - Pathology and Oncology …, 2022 - por-journal.com
… tumor microenvironment (TME), immunecolon cancer with DCs is related to tumor progression
and patient prognosis, suggesting a central role of DCs in controlling local tumor immunity

Identification of an immune gene signature based on tumor microenvironment characteristics in colon adenocarcinoma

Y Chen, J Zhao - Cell Transplantation, 2021 - journals.sagepub.com
colon adenocarcinoma (COAD). This study aimed to analyze the characteristics of the
immune microenvironment … risk factor for patients with colon cancer. The Gene Set Enrichment …

Advances in modeling the immune microenvironment of colorectal cancer

PS Yoon, N Del Piccolo, VS Shirure, Y Peng… - Frontiers in …, 2021 - frontiersin.org
… identify and lyse cells in murine- and patient-derived normal colon and CRC organoids, but
the effects are reduced by limited immune cell infiltration into organoids (73). Further, a 2019 …

Identification of novel tumor-microenvironment-regulating factor that facilitates tumor immune infiltration in colon cancer

Y Wang, Y Wang, C Xu, Y Liu, Z Huang - Molecular Therapy-Nucleic Acids, 2020 - cell.com
… the tumor microenvironment of colon cancer remain largely unknown. In this study, immune
… these genes were interacted with immune cells in remodeling immune microenvironment of …

Hydrogen sulfide creates a favorable immune microenvironment for colon cancer

T Yue, J Li, J Zhu, S Zuo, X Wang, Y Liu, J Liu, X Liu… - Cancer research, 2023 - AACR
… In summary, H 2 S depletion could create a favorable immune microenvironment in colon
cancer by decreasing the persulfidation of ENO1 in Tregs and ELK4 in CD8 + T cells. Our …

[HTML][HTML] Spatial and phenotypic immune profiling of metastatic colon cancer

J Lazarus, T Maj, JJ Smith, MP Lanfranca, A Rao… - JCI insight, 2018 - ncbi.nlm.nih.gov
… We set out to explore the immune microenvironment of colorectal cancer liver metastases
(… PD-L1 + APCs on shaping the immune microenvironment by enhancing Treg activity while …