… response (64). In contrast to the TD immune response, abrogation of the CD40/CD40L
pathway has no impact on the thymus-independent (TI) antibody response. When mice are …

… immunity. The focus of this review is on the role of the CD40L/CD40 costimulatory system in
… Comprehensive reviews on the overall biology of the CD40L/CD40 system can be found in …

… CD40-CD40L gene doses elicit different levels and functionally counteracting phenotypes of
T cell responses … on the strength of its CD40-CD40L-mediated cognate interaction with CD4 …

… contributor, the CD40/CD40 ligand (L) system, and present evidence that this system plays a
major role in immunity and inflammation… fits in the general scheme of an immune response. …

… responses to opportunistic bacterial infections. To address the role of CD40L in humoral
immunity, we created, through homologous recombination, mice deficient in CD40L expression. …

… where CD40 cross-linking occurs (5). In immune system, CD40CD40L interaction affects
some key processes, ie, immune cell activation, differentiation, proliferation, and apoptosis. …

… of immune cells. In the current study we examined the role of CD40-mediated interactions in
immune responses … lines using soluble human CD40L (rhCD40L) or anti-CD40 mAb in vitro. …

… dependent on signals provided through the CD40-CD40L interaction. However, novel …
CD40L and CD40 molecules may extend well beyond their role in the humoral immune response…

… of cell-mediated and humoral adaptive immunity (Pype et al., … of the CD40 with a deregulated
amount of CD40 ligand has … of CD40-CD40L mediated regulation of immune response …

… have studied immune responses of CD40Ldeficient mice following infection with these
viruses (65). Our results indicated severely compromised humoral immune responses in CD40L-…