The microbiome in systemic autoimmune disease: mechanistic insights from recent studies

C Dehner, R Fine, MA Kriegel - Current opinion in rheumatology, 2019 - journals.lww.com
… protective immunity against pathogens and prevent inflammatory immune responses against
… other isotypes marks pathobionts that elicit systemic immune responses as seen in non-gut …

Mechanistic insights into immune checkpoint inhibitor-related hypophysitis: a form of paraneoplastic syndrome

K Kanie, G Iguchi, H Bando, S Urai, H Shichi… - Cancer Immunology …, 2021 - Springer
… Because of enhanced immune responses, immune-related adverse events (irAEs), including
endocrinopathies such as hypophysitis, have been associated with the use of ICIs. Most …

Tumor metastasis: Mechanistic insights and therapeutic interventions

M Liu, J Yang, B Xu, X Zhang - MedComm, 2021 - Wiley Online Library
… in TME by inhibiting adaptive and innate immune responses. Here, we summarized the …
For example, Tregs impede CD8+T cell-mediated anti-tumor immune responses by inhibiting …

The pursuit of transplantation tolerance: new mechanistic insights

PK Gupta, CM McIntosh, AS Chong… - Cellular & Molecular …, 2019 - nature.com
… phase of the immune response within secondary … immune cell effector functions; thus,
Tbet + , IRF4 + , STAT-3/RORγt + , Bcl6 + Tregs can inhibit Th1, Th2, Th17, and Tfh responses, …

Mechanistic insights into the impact of air pollution on pneumococcal pathogenesis and transmission

D Beentjes, RK Shears, N French, DR Neill… - American Journal of …, 2022 - atsjournals.org
… of immune cells to the site of infection. However, an overactivated immune response may …
the impact that air pollution has on the immune responses that play a key role in controlling …

Vitiligo: mechanistic insights lead to novel treatments

ML Frisoli, JE Harris - Journal of Allergy and Clinical Immunology, 2017 - Elsevier
… Existing treatments for vitiligo (Table I) include topical steroids and calcineurin inhibitors,
which suppress immune responses in the superficial skin, where the immune infiltrate is located…

Evidence-based and mechanistic insights into exclusion diets for IBS

P Moayyedi, M Simren, P Bercik - Nature Reviews Gastroenterology & …, 2020 - nature.com
… In addition, the immune response related to food might be atypical and not driven by IgE.
A novel approach has been described 40 in which patients with IBS who did not show an IgE …

Mechanistic insights into ADXS11-001 human papillomavirus-associated cancer immunotherapy

BA Miles, BJ Monk, HP Safran - Gynecologic oncology research and …, 2017 - Springer
… Dendritic cells are an important link between the innate and adaptive immune responses,
with their activation in response to the TLR signaling cascade required for co-stimulation of T …

Immune evasion, a potential mechanism of trichothecenes: new insights into negative immune regulations

Q Wu, W Wu, TCC Franca, V Jacevic, X Wang… - International Journal of …, 2018 - mdpi.com
… system to allow pathogens to escape the host immune response [2]. We further suspect that
the immune evasion mechanism may have a relationship with the autophagy process, since …

A review on possible mechanistic insights of Nitazoxanide for repurposing in COVID-19

AS Lokhande, PV Devarajan - European Journal of Pharmacology, 2021 - Elsevier
… Furthermore, nitazoxanide displays the potential to boost host innate immune responses
and thereby tackle the life-threatening cytokine storm. Possibilities of improving lung, as well as …